This master thesis analyzes the use of synthesizers in film music and its influence on the development of film music from the early period and the first inventions to modern technology. The emphasis of the analysis is on analog instruments, the prinicple of operation, their components and functions, and the creative potential in integration into film scores. In addition to a brief history, the most important authors and their contributions are also listed. A comparative analysis of the film Blade Runner (1982) and its sequel Blade Runner 2049 (2017) was performed in order to see the similarities and differences in the compositional approach and to describe the influence of synthesizer on the genre and atmosphere of the film. An Iconical musical number Tears in Rain from the movie Blade Runner (1982) was deconstructed based on imitations by musician Dan Carr, who recreated all musical segments using virtual instruments. Following these examples, I independantly tried to perform an imitation of the song Wave Crasing on Distant Shores of Time from the series Black Mirror (ep. San Junipero), composed by the famous author Clint Mansell.