undergraduate thesis
Biochemical methods in the procedure of demonstrating the process of degeneration in the brain

Mariana Puškarić (2016)
Josip Juraj Strossmayer University of Osijek
Department of biology
Metadata
TitleBiokemijske metode u postupku dokazivanja procesa degeneracije u mozgu
AuthorMariana Puškarić
Mentor(s)Elizabeta Has Schon (thesis advisor)
Abstract
Neurodegenerativne bolesti odnose se na oštećenja mozga koja u većini slučajeva izazivaju demenciju i smrt neurona. U radu su objašnjene metode kojima se neurodegeneracije mogu dokazati i pomoću kojih se istražuju. Metode su podjeljenje na citogenetičke (in situ hibridizacija i fluorescentna in situ hibridizacija), imunohistokemijske (prepoznavanje ciljnih antigena pomoću određenih protutijela) i tehnike za vizualizaciju moždanog tkiva i aktivnosti moždanih stanica. Osim metoda za dokazivanje neurodegenerativnih bolesti, opisani su i biomarkeri neurodegeneracije i bolesti povezane s degeneracijom moždanog tkiva. Neke od bolesti su Alzheimer-ova bolest, Tay-Sach-ova bolest, Huntington-ova bolest, Parkinson-ova bolest i amiotrofična lateralna skleroza.
Keywordsneurodegeneration neurodegenerative diseases methods biomarkers
Parallel title (English)Biochemical methods in the procedure of demonstrating the process of degeneration in the brain
Committee MembersElizabeta Has Schon (committee chairperson)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineNATURAL SCIENCES
Biology
Study programme typeuniversity
Study levelundergraduate
Study programmeUndergraduate University Study Programme in Biology (Bachelor of Science)
Academic title abbreviationuniv.bacc.biol.
Genreundergraduate thesis
Language Croatian
Defense date2016-09-30
Parallel abstract (English)
Neurodegenerative diseases are associated with damage to the brain, which in most cases cause dementia and death of neurons. In this work we consider the methods used to prove neurodegeneration and by which they can be explaind. The methods are divided into cytogenetic methods (in situ hybridization and fluorescent in situ hybridization), immunohistochemical methods (recognition of target antigens by specific antibodies) and techniques for the visualization of brain tissue and brain-cell activity. In addition to methods for the detection of neurodegenerative diseases, here is also described the neurodegeneration biomarkers and disease associated with degeneration of the brain tissue. Some of the diseases are Alzheimer's disease, Tay-Sach's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis.
Parallel keywords (Croatian)neurodegeneracija neurodegenerativne bolesti metode biomarkeri
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:181:866420
CommitterVesna Radman Meic