undergraduate thesis
Excessive brain protein oxidation and enzyme dysfunction in Alzheimers disease

Sanela Louč (2016)
Sveučilište Josipa Jurja Strossmayera u Osijeku
Odjel za biologiju
Metadata
TitleSuvišna oksidacija proteina mozga i disfunkcija enzima kod Alzheimerove bolesti
AuthorSanela Louč
Mentor(s)Valentina Pavić (thesis advisor)
Abstract
Alzheimerova bolest je oblik progresivne demencije koju prate simptomi moždane atrofije. Suvišnom oksidacijom proteina koja je uzrokovana slobodnim radikalima dolazi do patoloških promjena na mozgu. Alzheimerovu bolest karakteriziraju senilni plakovi i neurofibrilarni čvorovi na mozgu. Uslijed oksidacije proteina i nitriranja tirozina aktivnost enzima koji sudjeluju u važnim metaboličkim procesima se smanjuje, što dovodi do neurodegeneracije koja je karakteristična za Alzheimerovu bolest.
KeywordsAlzheimer's disease protein oxidation oxidative stress nitration neurodegeneration
Parallel title (English)Excessive brain protein oxidation and enzyme dysfunction in Alzheimers disease
Committee MembersValentina Pavić (committee chairperson)
GranterSveučilište Josipa Jurja Strossmayera u Osijeku
Odjel za biologiju
PlaceOsijek
StateCroatia
Scientific field, discipline, subdisciplineNATURAL SCIENCES
Biology
Study programme typeuniversity
Study levelundergraduate
Study programmeUndergraduate University Study Programme in Biology (Bachelor of Science)
Academic title abbreviationuniv.bacc.biol.
Genreundergraduate thesis
Language Croatian
Defense date2016-09-19
Parallel abstract (English)
Alzheimer's disease is a form of progressive dementia with symptoms of brain atrophy. Excessive protein oxidation caused by free radicals leads to pathological changes in the brain. Alzheimer's disease is characterized by senile plaques and neurofibrillary tangles in the brain. Due to protein oxidation and nitration of tyrosine, activity of enzymes involved in important metabolic processes is reduced, which leads to neurodegeneration characteristic for Alzheimer's disease.
Parallel keywords (Croatian)Alzheimerova bolest oksidacija proteina oksidacijski stres nitriranje neurodegeneracija
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:181:809857
CommitterVesna Radman Meic