Studij sinteze konjugata azitromicina i klorina e6

Lijić, Martina

prikaz prve stranice dokumenta Studij sinteze konjugata azitromicina i klorina e6

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master's thesis

Studij sinteze konjugata azitromicina i klorina e6

Rijeka: University of Rijeka, 2017. urn:nbn:hr:193:074601

Lijić, Martina

University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

APA 6th Edition

Lijić, M. (2017). Studij sinteze konjugata azitromicina i klorina e6 (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:074601

MLA 8th Edition

Lijić, Martina. "Studij sinteze konjugata azitromicina i klorina e6." Master's thesis, University of Rijeka, 2017. https://urn.nsk.hr/urn:nbn:hr:193:074601

Chicago 17th Edition

Lijić, Martina. "Studij sinteze konjugata azitromicina i klorina e6." Master's thesis, University of Rijeka, 2017. https://urn.nsk.hr/urn:nbn:hr:193:074601

Harvard

Lijić, M. (2017). 'Studij sinteze konjugata azitromicina i klorina e6', Master's thesis, University of Rijeka, accessed 26 April 2024, https://urn.nsk.hr/urn:nbn:hr:193:074601

Vancouver

Lijić M. Studij sinteze konjugata azitromicina i klorina e6 [Master's thesis]. Rijeka: University of Rijeka; 2017 [cited 2024 April 26] Available at: https://urn.nsk.hr/urn:nbn:hr:193:074601

IEEE

M. Lijić, "Studij sinteze konjugata azitromicina i klorina e6", Master's thesis, University of Rijeka, Rijeka, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:193:074601

Cite this item: https://urn.nsk.hr/urn:nbn:hr:193:074601

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Metadata

Title	Studij sinteze konjugata azitromicina i klorina e6
Title (english)	Azithromycin and chlorine e6 conjugate synthesis study
Author	Martina Lijić
Mentor	Davor Margetić (mentor)
Mentor	Karlo Wittine (mentor)
Committee member	Davor Margetić (predsjednik povjerenstva)
Committee member	Karlo Wittine (član povjerenstva)
Committee member	Roberto Antolović (član povjerenstva)
Committee member	Elitza Petkova Markova - Car (član povjerenstva)
Granter	University of Rijeka (Faculty of Biotechnology and Drug Development) Rijeka
Defense date and country	2017-10-31, Croatia
Scientific / art field, discipline and subdiscipline	BIOTECHNICAL SCIENCES Biotechnology
Abstract	U ovom radu opisan je razvoj sinteze novoga konjugata azitromicina i klorina e6. Pripravljeni derivat azitromicina s aktiviranom 4''-O-acilimidazolilnom funkcionalnom skupinom i 13¹-etilendiaminski derivat klorina e6 su reakcijom amidnog vezanja u završnom stupnju paralelne sinteze povezani u željeni konjugat. Svim izoliranim spojevima strukture su potvrđene i okarakterizirane 1H i 13C NMR, UV/Vis i IR spektrima a završnom spoju 21 dodatno i 2D spektroskopijom COSY, NOESY i TOCSY. Svrha je sintetiziranih spojeva ispitivanje mogućnosti njihova korištenja u antimikrobnoj fotodinamičkoj terapiji.
Abstract (english)	This work describes the synthesis of a new conjugate of azithromycin and chlorine e6. The prepared azithromycin derivative with the activated 4"-O-acylimidazolyl functional group and the 13-ethylenediamine derivative of chlorine e6 are reacted with the amide bond in the final step of the parallel synthesis linked to the desired conjugate. All isolated structural compounds were confirmed and characterized by 1H and 13C NMR, UV/Vis and IR spectra and final compound 21 in addition to 2D COSY, NOESY and TOCSY spectroscopy. The purpose of the synthesized compounds is to investigate the possibility of their use in antimicrobial photodynamic therapy.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:193:074601
Study programme	Title: Medicinal chemistry Study programme type: university Study level: graduate Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resource	Text
File origin	Born digital
Access conditions	Access restricted to students and staff of home institution
Terms of use
Repository	Repository of the University of Rijeka, Faculty of Biotechnology and Drug Development
Created on	2018-01-15 09:16:09

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