Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi

Bracanović, Sara

prikaz prve stranice dokumenta Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi

master's thesis

Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi

Rijeka: University of Rijeka, 2018. urn:nbn:hr:193:980378

Bracanović, Sara

University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

APA 6th Edition

Bracanović, S. (2018). Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:980378

MLA 8th Edition

Bracanović, Sara. "Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi." Master's thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:980378

Chicago 17th Edition

Harvard

Bracanović, S. (2018). 'Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi', Master's thesis, University of Rijeka, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:193:980378

Vancouver

Bracanović S. Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi [Master's thesis]. Rijeka: University of Rijeka; 2018 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:193:980378

IEEE

S. Bracanović, "Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi", Master's thesis, University of Rijeka, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:193:980378

Cite this item: https://urn.nsk.hr/urn:nbn:hr:193:980378

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Title	Sinteza derivata 4H-tieno[3,2-c]kromen-4-ona i ispitivanje inhibitornih učinaka na pSTAT1 i pSTAT5 izoliranih iz mononuklearnih stanica periferne krvi
Title (english)	Synthesis of 4H-thieno[3,2-c]chromen-4-one derivatives and evaluation of their anti-inflammatory activity on pSTAT1 and pSTAT5 isolated from peripheral blood mononuclear cells
Author	Sara Bracanović
Mentor	Karlo Wittine (mentor)
Committee member	Dean Marković (predsjednik povjerenstva)
Committee member	Sandra Kraljević Pavelić (član povjerenstva)
Committee member	Karlo Wittine (član povjerenstva)
Granter	University of Rijeka (Faculty of Biotechnology and Drug Development) Rijeka
Defense date and country	2018-12-10, Croatia
Scientific / art field, discipline and subdiscipline	BIOTECHNICAL SCIENCES Biotechnology
Abstract	ovom radu opisana je sinteza tricikličkih angularnih spojeva, 4H-tieno[3,2-c]kromen-4-ona (7-8, 9a-e) i derivata (5-(2-hidroksi-4-metoksifenil) tiofen-2,4-di-il)dimetanola (5, 6a-d). Ispitana je protuupalna učinkovitost spojeva 4, 7, 8 i 9a-e in vitro, mjerenjem učinkovitosti inhibicije različitih fosfo-STAT proteina (engl. Signal Transducer and Activatior of Transcription) koji su dio JAK (engl. Janus kinase)/STAT signalnog puta. Spoj 7 (etil 7-hidroksi-4-okso-4H-tieno[3,2-c]kromen-2-karboksilat) pokazao je najbolja inhibicijska svojstva sa vrijednostima IC50 5,0 μM (pSTAT5/GM-CSF/PBMC); IC50 49,5 μM (pSTAT5/IL-2/PBMC) i IC50 10,50 μM (pSTAT1/IFN-/PBMC).
Abstract (english)	Synthesis of tricyclic angular compounds, namely 4H-thieno[3,2-c]chromen-4-one (7-8, 9a-e) and (5-(2-hydroxy-4-methoxyphenyl) thiophene-2,4-diyl)dimethanol (5, 6a-d) derivatives, is described. Compounds 4, 7, 8 and 9a-e were tested in vitro for their anti-inflammatory activity, by measuring various pSTAT (signal transducer and activator of transcription) inhibition within the JAK (Janus-activated family kinase)/STAT signaling pathway. Compound 7 (ethyl 7-hydroxy-4-oxo-4H-thieno[3,2-c]chromene-2-carboxylate) showed best inhibition properties on inhibition of pSTAT5 in GM-CSF-triggered assay, with IC50 value of 5.0 μM. Inhibition of pSTAT5 in IL-2-triggered assay showed IC50 value of 49.5 μM, while inhibition of pSTAT1 in IFN--triggered assay showed IC50 value of 10.5 μM.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:193:980378
Study programme	Title: Medicinal chemistry Study programme type: university Study level: graduate Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access Embargo expiration date: 2020-01-01
Terms of use
Repository	Repository of the University of Rijeka, Faculty of Biotechnology and Drug Development
Created on	2018-12-20 08:48:32

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