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undergraduate thesis
Fusobacterium nucleatum: universal colonizer
Rijeka: University of Rijeka, 2021. urn:nbn:hr:193:426139
Nedeljković, Ema
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Nedeljković, E. (2021). Fusobacterium nucleatum: universal colonizer (Undergraduate thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:426139

Nedeljković, Ema. "Fusobacterium nucleatum: universal colonizer." Undergraduate thesis, University of Rijeka, 2021. https://urn.nsk.hr/urn:nbn:hr:193:426139

Nedeljković, Ema. "Fusobacterium nucleatum: universal colonizer." Undergraduate thesis, University of Rijeka, 2021. https://urn.nsk.hr/urn:nbn:hr:193:426139

Nedeljković, E. (2021). 'Fusobacterium nucleatum: universal colonizer', Undergraduate thesis, University of Rijeka, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:193:426139

Nedeljković E. Fusobacterium nucleatum: universal colonizer [Undergraduate thesis]. Rijeka: University of Rijeka; 2021 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:193:426139

E. Nedeljković, "Fusobacterium nucleatum: universal colonizer", Undergraduate thesis, University of Rijeka, Rijeka, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:193:426139

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Metadata
TitleFusobacterium nucleatum: universal colonizer
AuthorEma Nedeljković
MentorŽeljka Maglica (mentor)
Committee memberJelena Ban (predsjednik povjerenstva)
Committee memberNicholas James Bradshaw (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2021-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Fusobacterium nucleatum is a Gram-negative obligate anaerobic bacterium in the oral cavity. It plays a role in several oral diseases, including periodontitis and gingivitis but is also associated with a wide spectrum of human diseases throughout the body. The FadA adhesin conserved in F. nucleatum is a key virulence factor and a potential diagnostic marker for F. nucleatum-associated diseases. This thesis reviews F. nucleatum’s implication in periodontitis, colorectal cancer and adverse pregnancy outcomes. The pathogenic mechanisms involved in these diseases are discussed, with a particular emphasis on invasion, colonization, and induction of host inflammatory and tumorigenic responses. Biomarkers are also highlighted in order to improve diagnosis and subsequent treatment of these diseases.
Abstract (croatian)
Fusobacterium nucleatum je gram-negativna obligatna anaerobna bakterija koja obitava u usnoj šupljini. Igra ulogu u nekoliko oralnih bolesti, uključujući parodontitis i gingivitis, ali je također povezana sa širokim spektrom ljudskih bolesti koje obuhvaćaju cijelo tijelo. Adhezin FadA konzerviran u F. nucleatum-u ključni je faktor virulencije i potencijalni dijagnostički marker za bolesti povezane s F. nucleatum-om. Ovaj rad razmatra implikacije F. nucleatum-a u parodontitisu, kolorektalnom karcinomu i nepovoljnim ishodima trudnoće. U radu se opisuju patogeni mehanizmi uključeni u ove bolesti, s posebnim naglaskom na invaziju, kolonizaciju i indukciju upalnih i tumorigenih odgovora domaćina. Biomarkeri su također istaknuti kako bi se poboljšala dijagnoza i liječenje navedenih bolesti.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:193:426139
Study programmeTitle: Biotechnology and drug research
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova (sveučilišni/a prvostupnik/prvostupnica biotehnologije i istraživanja lijekova)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of the University of Rijeka, Faculty of Biotechnology and Drug Development
Created on2021-09-21 10:59:20

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