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master's thesis
Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihovih protuupalnih učinaka
Rijeka: University of Rijeka, 2018. urn:nbn:hr:193:364468
Jardas, Eda
University of Rijeka
Faculty of Biotechnology and Drug Development

Cite this document

Jardas, E. (2018). Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihovih protuupalnih učinaka (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:364468

Jardas, Eda. "Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihovih protuupalnih učinaka." Master's thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:364468

Jardas, Eda. "Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihovih protuupalnih učinaka." Master's thesis, University of Rijeka, 2018. https://urn.nsk.hr/urn:nbn:hr:193:364468

Jardas, E. (2018). 'Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihovih protuupalnih učinaka', Master's thesis, University of Rijeka, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:193:364468

Jardas E. Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihovih protuupalnih učinaka [Master's thesis]. Rijeka: University of Rijeka; 2018 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:193:364468

E. Jardas, "Sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihovih protuupalnih učinaka", Master's thesis, University of Rijeka, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:193:364468

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Metadata
TitleSinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih derivata radi ispitivanja njihovih protuupalnih učinaka
Title (english)Synthesis of 4,5-dihydrobenzo[b]thieno[2,3-d]oxepine derivatives for their anti-inflammatory activity evaluation
AuthorEda Jardas
MentorKarlo Wittine (mentor)
Committee memberNela Malatesti (predsjednik povjerenstva)
Committee memberSandra Kraljević Pavelić (član povjerenstva)
Committee memberKarlo Wittine (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2018-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U sklopu ovog rada provedena je sinteza 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih analoga uključujući amide 6a i b, kiselinu 7, alkohol 8 te pet različitih aminoalkoksi derivata 9a-e. Ključni intermedijari u sintezi ovih spojeva su dva metoksi regioizomera 4,5-dihidrobenzo[b]tieno[2,3-d]oksepinskih estera (5a i 5b). Strukture svih spojeva razjašnjene su na temelju njihovih 1H i 13C NMR spektara. Ispitat će se protuupalna učinkovitost svih heterocikličkih spojeva sa zavinutom strukturom, posebice inhibicija TNF-α i protuupalnih citokina poput IL2 i IFNγ. Dobivena aktivnost će se usporediti sa aktivnošću sličnih spojeva opisanih u literaturi i analozima prethodno dobivenim u našem laboratoriju.
Abstract (english)
Within this thesis synthesis of different 4,5-dihydrobenzo[b]thieno[2,3-d]oxepine derivatives including amides 6a, b, acid 7, alcohol 8 and five different aminoalkoxy derivatives 9a-e was performed. A key intermediates for these compounds were two methoxy regioisomers of 4,5-dihydrobenzo[b]thieno[2,3-d]oxepine esters (5a and 5b). The structures of all prepared compounds were elucidated based on their 1H and 13C NMR spectra. All angular heterocyclic compounds are aimed for testing their anti-inflammatory activity, particularly inhibition of TNF-α and pro-inflammatory cytokines such as IL2 and IFNγ and comparison to the inhibitory activity of similar compounds described in the literature and analogs previously obtained in our group.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:364468
Study programmeTitle: Medicinal chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
RepositoryRepository of the University of Rijeka, Faculty of Biotechnology and Drug Development
Created on2018-07-25 07:51:09

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