Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6

Cvitan, Ana

prikaz prve stranice dokumenta Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6

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master's thesis

Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6

Rijeka: University of Rijeka, 2016. urn:nbn:hr:193:524352

Cvitan, Ana

University of Rijeka
Department of Biotechnology

Cite this document

APA 6th Edition

Cvitan, A. (2016). Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6 (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:524352

MLA 8th Edition

Cvitan, Ana. "Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6." Master's thesis, University of Rijeka, 2016. https://urn.nsk.hr/urn:nbn:hr:193:524352

Chicago 17th Edition

Cvitan, Ana. "Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6." Master's thesis, University of Rijeka, 2016. https://urn.nsk.hr/urn:nbn:hr:193:524352

Harvard

Cvitan, A. (2016). 'Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6', Master's thesis, University of Rijeka, accessed 28 March 2023, https://urn.nsk.hr/urn:nbn:hr:193:524352

Vancouver

Cvitan A. Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6 [Master's thesis]. Rijeka: University of Rijeka; 2016 [cited 2023 March 28] Available at: https://urn.nsk.hr/urn:nbn:hr:193:524352

IEEE

A. Cvitan, "Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6", Master's thesis, University of Rijeka, Rijeka, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:193:524352

Cite this item: https://urn.nsk.hr/urn:nbn:hr:193:524352

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Metadata

Title	Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6
Title (english)	Applications of peptide coupling to synthesis of selected 15^2-amino derivatives of chlorin eˇ6
Author	Ana Cvitan
Mentor	Davor Margetić (mentor)
Committee member	Davor Margetić (predsjednik povjerenstva)
Committee member	Jasminka Giacometti (član povjerenstva)
Committee member	Mladenka Malenica Staver (član povjerenstva)
Granter	University of Rijeka (Department of Biotechnology) Rijeka
Defense date and country	2016-09-16, Croatia
Scientific / art field, discipline and subdiscipline	BIOTECHNICAL SCIENCES Biotechnology
Abstract	U svrhu korištenja porfirinskih derivata u fotodinamičkoj terapiji sintetski je pripravljen 152-konjugat klorina e6 i 2-(2-piridil)etilamina. U ovisnosti o reakcijskim uvjetima i reagensima korištenim za peptidno vezanje, nastaju različite smjese u kojima dominira 152-konjugat, u odnosu na 152,173-biskonjugat. Reakcijski mehanizam njihova nastanka i reaktivnosti klorina e6 su diskutirani. Optimizacija reakcije dobivanja 131,152-anhidrida klorina e6 nije dovela do njegove priprave u čistom obliku pogodnom za korištenje za konjugaciju s aminima. Nadalje je pokazano kako direktna 152-konjugacija klorina e6 i triptamina peptidnim vezanjem dovodi do djelomičnog stvaranja produkta. Peptidno vezanje je također korišteno za pripravu novog 131-konjugata klorina e6 i triptofana a korištenjem reagensa za peptidno vezanje. Struktura novopripravljenog spoja je okarakterizirana 1D i 2D NMR (COSY i NOESY), UV/VIS i IR spektroskopijom, te masenom spektrometrijom. Analogna reakcija sa nikotinskom kiselinom nije bila uspješna.
Abstract (english)	For the purpose of use of porphyrin derivatives in photodynamic therapy, new 152-conjugate of chlorin e6 and 2-(2-pyridyl)ethylamine was prepared. Depending on reaction conditions and reagents used in peptide coupling, different mixtures were synthesized, with major product the 152-conjugate. In this master thesis reaction mechanism and reactivity of chlorine e6 is discussed. Optimization of synthesis of 131,152-chlorine e6 anhydride did not lead to its pure state appropriate for amine conjugation. Furthermore is shown that direct conjugation of 152-chlorine e6 and tryptamine by peptide coupling leads to partial product synthesis. Peptide coupling was also used for the preparation of new 131-chlorine e6 conjugate and tryptophan with application of peptide coupling reagents. New compound structure was characterized by 1D and 2D NMR (COSY and NOESY), UV/VIS and IR spectroscopy and also by mass spectrometry. Analogous reaction with nicotic acid was not successful.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:193:524352
Study programme	Title: Medicinal chemistry Study programme type: university Study level: graduate Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resource	Text
File origin	Born digital
Access conditions	Closed access
Terms of use
Repository	Repository of the University of Rijeka, Department of Biotechnology
Created on	2016-10-21 11:41:15