This paper provides an overview of methods that could be used to measure the lipophilicity of tripyridylporphyrins. Porphyrins are potentially good photosensitizers used in photodynamic therapy because they have good photophysical properties and their synthesis is simple. The importance of lipophilicity testing stems from the fact that a good photosensitizer is characterized by selectivity for tumor cells, which is influenced by lipophilicity. Lipophilicity is measured as the distribution of a drug molecule between the organic phase (octan-1-ol) and the aqueous phase expressed as logP. Thus, the logP value in different solvents was determined in comparison with the reference value of octan-1-ol and water. Two compounds were used: 5- (4-octadecanamidophenyl) -10,15,20-tris (1-oxido-3-pyridyl) porphyrin and 5- (4-amidophenyl) -10,15,20-tris (1-oxido) -3-pyridyl) porphyrin and six different solvents which included: methanol, butan-1-ol, octan-1-ol, octan-2-ol, PBS (phpsphate buffer saline) and water. The experimental part consists of two parts. In the first part, the solubility of these two compounds in solvents was examined by UV-Vis spectroscopy, the absorption spectrum was obtained from which the molar absorption coefficient was then calculated, which was used in the further procedure to calculate the values of the partition coefficient. The second part of the experiment involved determining the Rf value by thin layer chromatography and using the shake-flask method to finally determine the partition coefficient. The results showed that these two compounds were best dissolved in butan-1-ol. and that this solvent, in combination with the reference octan-1-ol, is optimal for determining the logP value for tripyridylporphyrins.