Colorectal cancer is one of the most common cancers that occurs in both sexes. Apart from oncology, the only treatment method is surgery. Ostomy is a temporary or permanent opening on the abdominal wall, derived from a healthy part of the colon, depending on which part of colon is derived, there is colostomy (colon) and ileostomy (small intestine). Although ostomies are also performed in non-malignant diseases (ulcerative colitis, Chron's disease, stab wounds, birth anomalies), it is still most commonly performed in malignant diseases. Recently, the notion of enterostomal therapist has become more known, their field of work is a patient who has a stoma. The domain of work of this specialized nurse is not only the care of patients with ostomy, but of all patients with malignant diseases as well as the prevention of diseases. Nurses educate patients and their families about the changes that will occur after colostomy is performed. Special attention is given to colostomy care, nutrition, intimate life, pregnancy, return to work, sports, and daily life activities. This paper describes the basic anatomy of the colon; diagnosis and treatment of colorectal cancer; the stomas that are used and their complications. The role of the nurse in preoperative and postoperative patient care, psychological approach and education of patients with colorectal cancer will also be presented.