Although vaccination is a proven measure to have the most successful prevention of infectious diseases, it has been unjustifiably questioned in recent years. The final paper on the topic "Vaccination of children as a challenge of today" aimed to determi ne the attitudes of students of the first, second and third year of full time undergraduate study of nursing in Rijeka on the vaccination of children. The final paper consists of two parts, the first part talks about the historical development of vaccines and vaccinations, vaccination coverage in the Republic of Croatia, about different types of vaccines and the method of application. The Mandatory Vaccination Program, legal regulation and the vaccination declaration are described. Emphasis was placed on the anti vaccination movement in the world and in the Republic of Croatia and on vaccination from the perspective of parents. The second part of the final work consists of research and data processing. A total of 87 students' answers to 16 questions from the anonymous questionnaire were processed and analyzed. The answers to all the questions individually are processed numerically and in percentages, in bar and pie charts.