Introduction: The quality of life can be defined as experiencing own life in a subjective way that is determined by the environment in which we live, the people who surround us and the lifestyle. Physical activity contributes to psychological health and prevents various somatic diseases. Studies conducted on this topic find that physically less active children have a worse result in the psychosocial domain and in the overall quality of life. Sport allows learning of skills and attitudes that are important later in adulthood. The child also develops self-esteem and perseverance, and psychosocial development develops and adopts adaptive forms of experience and behavior. Aim: The aim of this study is to determine the difference in the quality of life in female athletes and no athletes. The influence of physical health on quality of life. Emotional health effects on mood, everyday life problems and ubiquitous stress which children are exposed to in school and extra-curricular activities. To study the social activities and school-related activities such as concentration, forgetfulness, and possible diseases that affect education. Participants and Methods: In this research included 22 girls of school age from 8-14 years who regularly three times a week to train the handball and 20 girls in the control group of the same age who are not involved in sports. Girls included in the study were subjected to examination through a poll by the general quality of life. Their parents have given written consent to their children, are eligible to participate in the survey for the purpose of making this final work. Results: The results showed that the athletes physically healthier than no athletes. Quality of life related to emotional well-being is being very close. And that goes for the social, school activities, and psychological and social health. Determine the correlation relationship between the physical and psychosocial health at female athletes, as long as the code is not no athletes. Also statistically determined by the positive connection between physical health and school activities, and at the no athletes proved to be a negative correlation. Conclusion: The survey is determined by a better quality of life related to physical health at female athletes compared to the control group. He also established a positive correlation between physical health and psychosocial health and school activities at female athletes, unlike the control group. Or in one group has not been established a connection between physical health and emotional health and social activities