Ankylosing spondylitis (AS), also known as Bekhterew's disease, is a chronic multisystem inflammatory disease that belongs to a class of seronegative spondyloarthritides. It mainly affects joints in the spine and the sacroiliac joint in the pelvis, causing complete fusion and even destructive lesions. Ankylosing spondylitis (AS) is an autoimmune diesease strongly associated with HLA-B27 gene. General onset of AS commonly occurs in younger people, mostly men, between the ages of 18 and 30. People who have an affected family member are 10 to 20 times more likely to devolop AS. Teh hallmark features of AS are inlammation symptoms characterized by acute, painful episodes, followed by temporary periods of remission where symptoms subside. The initial symptom is usually a chronic dull pain in the lower back. Pain is often severe at rest, combined with stiffness of the lower back in the morning that improves with physical activity. Treatments for AS include medication, physiotherapy and exercises. Daily physical therapy is essential for maintaining the quality of life and improving the psychosocial status in patients with AS. It includes spinal exercises and breathing exercises. The goal of treatment is to gradually alleviate pain, maintain good posture, flexibility and muscle strenght.