Djelovanje oleuropeina iz ekstrakta lista divlje masline na apoptozu različitih staničnih linija humanih karcinoma

Jerinić, Robert

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master's thesis

Djelovanje oleuropeina iz ekstrakta lista divlje masline na apoptozu različitih staničnih linija humanih karcinoma

diplomski rad

Split: University of Split, Faculty of Chemistry and Technology, 2017. urn:nbn:hr:167:114214

Jerinić, Robert

University of Split
Faculty of Chemistry and Technology
University of Split
School of Medicine

Cite this document

APA 6th Edition

Jerinić, R. (2017). Djelovanje oleuropeina iz ekstrakta lista divlje masline na apoptozu različitih staničnih linija humanih karcinoma : diplomski rad (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:114214

MLA 8th Edition

Jerinić, Robert. "Djelovanje oleuropeina iz ekstrakta lista divlje masline na apoptozu različitih staničnih linija humanih karcinoma : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology; University of Split, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:167:114214

Chicago 17th Edition

Harvard

Jerinić, R. (2017). 'Djelovanje oleuropeina iz ekstrakta lista divlje masline na apoptozu različitih staničnih linija humanih karcinoma : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology; University of Split, School of Medicine, accessed 22 January 2021, https://urn.nsk.hr/urn:nbn:hr:167:114214

Vancouver

Jerinić R. Djelovanje oleuropeina iz ekstrakta lista divlje masline na apoptozu različitih staničnih linija humanih karcinoma : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; Split: University of Split, School of Medicine; 2017 [cited 2021 January 22] Available at: https://urn.nsk.hr/urn:nbn:hr:167:114214

IEEE

R. Jerinić, "Djelovanje oleuropeina iz ekstrakta lista divlje masline na apoptozu različitih staničnih linija humanih karcinoma : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split; University of Split, School of Medicine, Split, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:167:114214

Cite this item: https://urn.nsk.hr/urn:nbn:hr:167:114214

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Metadata

Title	Djelovanje oleuropeina iz ekstrakta lista divlje masline na apoptozu različitih staničnih linija humanih karcinoma : diplomski rad
Title (english)	Effects of oleuropein extracted from wild olives leaf on apoptosis of varius cell lines of human cancers : diploma thesis
Author	Robert Jerinić
Mentor	Vedrana Čikeš Čulić (mentor)
Committee member	Janoš Terzić (predsjednik povjerenstva)
Committee member	Ivana Mudnić (član povjerenstva)
Committee member	Vedrana Čikeš Čulić (član povjerenstva)
Granter	University of Split Faculty of Chemistry and Technology Split
Granter	University of Split School of Medicine Split
Defense date and country	2017-09-19, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy
Abstract	Ispitati učinak apoptoze na staničnim linijama karcinoma dojke MDA-MB-231, mokraćnog mjehura T24 i glioblastoma A1235. Pretpostavka je da će se nakon izlaganja karcinomskih staničnih linija oleuropeinom smanjiti stupanj preživljavanja stanica. Učinak oleuropeina na stanične linije karcinoma dojke MDA-MB-231, mokraćnog mjehura T24 i glioblastoma A1235 praćen je protočnom citometrijom. In vitro izlaganje stanica karcinoma dojke MDA-MB-231, mokraćnog mjehura T24 i glioblastoma A1235 ekstraktom oleuropeina dovelo je do smanjenja preživljavanja ispitivanih stanica karcinoma. Stupanj apoptoze kod karcinoma stanica dojke MDA-MB-231 nije proporcionalno s koncentracijom oleuropeina. Stupanj apoptoze kod karcinoma stanica glioblastoma A1235 proporcionalno je s koncentracijom oleuropeina. Najveći stupanj apoptoze uočen je na stanicama glioblastoma A1235 pri koncentraciji oleuropeina 0,5 µM. Najmanji stupanj apoptoze uočen je na stanicama mokraćnog mjehura T-24 pri koncentraciji oleuropeina 0,1 µM. Potrebna su dodatna istraživanja kako bi se utvrdili točni mehanizmi učinka oleuropeina na karcinomske stanice.
Abstract (english)	The effect of oleuropein on apoptosis of breast cancer cell lines MDA-MB-231, bladder cancer T-24 and glioblastoma A1235. The assumption is that exposure to carcinoma cell line with oleuropein reduces the survival of cells. The effects of oleuropeina on breast cancer cell line MDA-MB-231, bladder cancer T-24 and glioblastoma A-1235 cell lines were estimated by the flow cytometry. In vitro exposure of MDA-MB-231, T24 and A1235 cells to oleuropein decreased a survival of cancer cells. The degree of apoptosis in MDA-MB-231 cells is not in proportion with the concentration of oleuropein. The degree of apoptosis in A1235 cells is in proportion with the concentration of oleuropein. The highest effect of oleuropein was found in A1235 cells treated with 0.5 µM oleuropein. In the other hand, the minimum degree of apoptosis was observed in T24 cell treated by oleuropein at the concentration of 0.1 µM. To summarize this, additional research is required to elucidate a precise mechanism of oleuropein effects on cancer cells.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:167:114214
Study programme	Title: Pharmacy Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Public note	Ključne riječi doradio knjižničar/ Key words are revised by the librarian
Repository	Repository of the Faculty of chemistry and technology
Created on	2018-07-26 10:38:29

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