Physicians are exposed to the specific risk factors in their work environment that could subsequently cause specific, occupational disease. The aim of the research was to present the analysis of mortality statistics of physicians up to 65 years old in Primorsko-goranska County who died in the period from 1994 to 2012. Analysis of mortality showed that the most common cause of death in both sexes are malignant neoplasms with a share of 38,4%, with malignant neoplasm of the brain as most frequent diagnosis. Malignant neoplasms are the most common cause of death in women, with a share of mortality of 62,5%, of which the most common malignant neoplasm are the brain tumor and breast cancer. The most frequent cause of death in men is malignant neoplasm of the prostate. Circulatory diseases are the second most common cause of death in both sexes, with a share of 32.8%, and the most frequently diagnosed is acute myocardial infarction. In men, cardiovascular diseases are the leading cause of death, accounting for 48.4%, while the largest proportion of the mortality has acute myocardial infarction. Among other diseases are the most common injuries, poisoning and other consequences of external causes, of which more than half are consequence of suicide. Physicians have a lower proportion of the mortality of certain diseases that are related with lifestyle, such as metabolic and respiratory diseases and lung cancer, but are more likely to die as a result of breast cancer and suicide than the general population. Further research of mortality among Croatian physicians is needed that would link lifestyle and health habits with certain specifics of mortality.