Prognostički značaj fluorescencijske in situ hibridizacije (FISH) u bolesnika s kroničnom limfocitnom leukemijom

Drmić, Željka

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master's thesis

Prognostički značaj fluorescencijske in situ hibridizacije (FISH) u bolesnika s kroničnom limfocitnom leukemijom

Zagreb: University of Zagreb, School of Medicine, 2017. urn:nbn:hr:105:616993

Drmić, Željka

University of Zagreb
School of Medicine
Department of Internal Medicine

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APA 6th Edition

Drmić, Ž. (2017). Prognostički značaj fluorescencijske in situ hibridizacije (FISH) u bolesnika s kroničnom limfocitnom leukemijom (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:616993

MLA 8th Edition

Drmić, Željka. "Prognostički značaj fluorescencijske in situ hibridizacije (FISH) u bolesnika s kroničnom limfocitnom leukemijom." Master's thesis, University of Zagreb, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:105:616993

Chicago 17th Edition

Harvard

Drmić, Ž. (2017). 'Prognostički značaj fluorescencijske in situ hibridizacije (FISH) u bolesnika s kroničnom limfocitnom leukemijom', Master's thesis, University of Zagreb, School of Medicine, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:616993

Vancouver

Drmić Ž. Prognostički značaj fluorescencijske in situ hibridizacije (FISH) u bolesnika s kroničnom limfocitnom leukemijom [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2017 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:105:616993

IEEE

Ž. Drmić, "Prognostički značaj fluorescencijske in situ hibridizacije (FISH) u bolesnika s kroničnom limfocitnom leukemijom", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:105:616993

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:616993

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Metadata

Title	Prognostički značaj fluorescencijske in situ hibridizacije (FISH) u bolesnika s kroničnom limfocitnom leukemijom
Title (english)	Prognostic value of fluorescence in situ hybridization (FISH) in patients with chronic lymphocytic leukemia
Author	Željka Drmić
Mentor	Slobodanka Ostojić-Kolonić (mentor)
Committee member	Ana Planinc-Peraica (predsjednik povjerenstva)
Committee member	Slavko Gašparov (član povjerenstva)
Committee member	Slobodanka Ostojić-Kolonić (član povjerenstva)
Granter	University of Zagreb School of Medicine (Department of Internal Medicine) Zagreb
Defense date and country	2017-07-14, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Internal Medicine
Abstract	Flourescencijska in situ hibridizacija omogućila je detekciju citogenetskih promjena u bolesnika s kroničnom limfocitnom leukemijom. Ova metoda koristi se u dijagnostičkoj obradi bolesnika prije inicijacije kemoimunoterapije. Ova retrospektivna studija obuhvatila je 70 novodijagnosticiranih bolesnika u razdoblju između 2013. i 2017. godine s ciljem praćenja ishoda bolesti, odnosno brzine progresije bolesti i odgovora na konvencionalnu terapiju u odnosu na nalaz citogenetskih promjena, uzimajući u obzir i druge prognostičke čimbenike dobi, spola te kliničkog stadija. Citogenetske promjene nađene su u 20 bolesnika. Najčešći nalaz bila je delecija 13q14 (16%), zatim 17p (9%), dok su delecija 11p i trisomija 12 nađene u samo jednog bolesnika. Iako je broj bolesnika s nađenim citogenetskim promjenama bio malen, nađene su statistički značajne razlike u OS-u i PFS-u među skupinama, gdje se istaknula delecija 17p kao citogenetska promjena najlošijeg ishoda.
Abstract (english)	Flourescence in situ hybridization has improved the detection of genomic aberrations in patients with chronic lymphocytic leukemia (CLL). This method is used to identify chromosomal abnormalities in patients with CLL before treating a patient on protocol . We applied FISH to blood smear samples from all newly diagnosed patients with CLL in the period from 2013 to 2017. Overall survival and progression free survival in 70 patients were analysed to evaluate prognosis regarding chromosomal aberrations, age, gender, Binet and Rai stage. Chromosomal aberrations were found in 20 of 70 patients. Most frequent aberrations were deletions in 13q14 (16%), 17p (9%), while deletion 11q and trisomy 12 were found in one patient. Patients with 17p deletion had the shortest progression free survival and overall survival. In conclusion, FISH is an important prognostic factor of disease progression and overall survival.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:105:616993
Study programme	Title: Medicine Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Dr Med - University of Zagreb School of Medicine Digital Repository
Created on	2018-03-26 08:48:13

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