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master's thesis
Suvremeni pristup liječenju melanoma
Zagreb: University of Zagreb, School of Medicine, 2015. urn:nbn:hr:105:144202
Kovačević, Petra
University of Zagreb
School of Medicine
Department of Dermatology

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Kovačević, P. (2015). Suvremeni pristup liječenju melanoma (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:144202

Kovačević, Petra. "Suvremeni pristup liječenju melanoma." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:144202

Kovačević, Petra. "Suvremeni pristup liječenju melanoma." Master's thesis, University of Zagreb, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:105:144202

Kovačević, P. (2015). 'Suvremeni pristup liječenju melanoma', Master's thesis, University of Zagreb, School of Medicine, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:144202

Kovačević P. Suvremeni pristup liječenju melanoma [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2015 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:105:144202

P. Kovačević, "Suvremeni pristup liječenju melanoma", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:105:144202

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Metadata
TitleSuvremeni pristup liječenju melanoma
Title (english)Modern approach to the treatment of melanoma
AuthorPetra Kovačević
MentorRomana Čeović (mentor)
Committee memberZrinka Bukvić Mokos (predsjednik povjerenstva)
Committee memberKrešimir Kostović (član povjerenstva)
Committee memberRomana Čeović (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Dermatology)
Zagreb
Defense date and country2015-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract
Melanom je zloćudni tumor podrijetlom od melanocita koji se ubraja među najzloćudnije tumore kože i sluznica. Zloćudnost ovog tumora očituje se u izrazitoj sklonosti ranom limfogenom i hematogenom metastaziranju. Incidencija melanoma u stalnom je porastu posljednjih desetljeća. Uglavnom se pojavljuje u osoba srednje životne dobi, češće u osoba fototipa 1 i 2. Sumnju na melanom moguće je postaviti kada se na koži nalazi pigmentirana lezija koja se mijenja tijekom vremena. Svakoj kožnoj leziji kod koje se primjeti promjena u boji, obliku, rubovima ili veličini treba posvetiti pozornost prema tzv. ABCDEFG pravilu. Kliničke značajke melanoma razlikuju se ovisno o anatomskoj lokalizaciji i tipu rasta lezije. Klinički se razlikuju četiri glavna tipa rasta melanoma: površinski šireći melanom, nodularni melanom, lentigo maligni melanom i akralni lentiginozni melanom. Dijagnoza melanoma postavlja se na temelju kliničkog i dermatoskopskog pregleda, a potvrđuje patohistološkom analizom bioptata pigmentirane lezije odstranjene u cijelosti. Ukoliko se dijagnosticira u ranoj fazi, melanom se u visokom postotku uspješno liječi kirurškom ekscizijom. Kod uznapredovalih stadija melanoma uz kemoterapiju i radioterapiju koriste se i brojni suvremeni načini liječenja, npr. ciljane terapije genetskih mutacija u melanomu i imunomodulatorna terapija. U bolesnika oboljelih od melanoma iznimno je važno provoditi redovite kontrolne kliničke preglede te pridržavati se svih oblika fotozaštite.
Abstract (english)
Melanoma is a malignant tumor derived from melanocytes. Malignancy of this tumor is evident in the strong tendency for lymphatic and hematogenous metastases.The incidence of melanoma has steadily increased in recent decades. It usually occurs in middle-aged, more often in people with phototype 1 and 2. The suspicion of melanoma arises when a pigmented lesion which varies in time appears on the skin. In every skin lesion that has changes in color, shape, borders or size, attention should be paid to the ABCDEFG rule. However, clinical features of melanoma vary depending on the localization and type of a lesion growth. Clinically there are four main types of melanoma: superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma and acral lentiginous melanoma. Diagnosis of melanoma is based on clinical examination and dermoscopy. Namely, the confirmation of diagnosis is being done by histopathological analysis of biopsy of pigmented lesion. When diagnosed in early phase, melanoma is highly curable with a surgical excision. However, in advanced stages, except chemotherapy and radiotherapy, some modern methods of treatment are being used, for example targeted therapy of genetic mutations in melanoma and immunotherapy. In patients with melanoma it is extremely important to provide regular clinical check- ups, as well as comply with the rules of photoprotection.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:144202
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryDr Med - University of Zagreb School of Medicine Digital Repository
Created on2016-03-31 07:25:30

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