Title Migrena Title (english) Migraine Author Tihana Biškup Mentor Damir Petravić (mentor)Committee member Zdravka Poljaković (predsjednik povjerenstva)Committee member Mario Habek (član povjerenstva)Committee member Damir Petravić (član povjerenstva)Granter University of Zagreb Defense date and country 2016-07-15, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Migrena je primarna glavobolja, čija prevalencija u općoj populaciji Europske unije iznosi 15%. Može se javiti epizodički, a može biti i kronična. Klinički je karakterizirana onesposobljavajućom, unilateralnom, pulsirajućom glavoboljom, trajanja 4 do 72 sata, praćenom mučninom i povraćanjem te fotofobijom, fonofobijom i osmofobijom.
Godišnji troškovi migrene, direktni vezani uz dijagnostiku i terapiju te indirektni vezani uz izostanke s posla, procjenjuju se u Europskoj uniji na 5 milijardi eura. Stoga migrena predstavlja ne samo medicinski, već i socioekonomski problem.
Točan uzrok migrenske glavobolje nije poznat, a zbog učestale pozitivne obiteljske anamneze smatra se da su u podlozi i genetski čimbenici. Prema današnjem shvaćanju u patogenezi migrenske glavobolje središnje mjesto zauzima aktivacija trigeminovaskularnog sustava s posljedičnom neurogenom inflamacijom i dilatacijom intrakranijskih krvnih žila inerviranih od C vlakana trigeminalnog živca.
Dijagnoza migrene postavlja se na temelju kliničke slike i simptoma, a prema kriterijima Međunarodnog društva za glavobolju (International Headache Society) svrstava se u jednu od podvrsta - migrenu bez aure i migrenu s aurom.
Terapija migrene je prema preporukama Europske federacije neuroloških društava (European Federation of Neurological Societies) abortivna – usmjerena na prekidanje glavobolje i ublažavanje pratećih simptoma te profilaktička – usmjerena prevenciji nastanka istih. U abortivnoj terapiji mogu se koristiti lijekovi iz skupina nesteroidnih antiinflamatornih lijekova ili triptana, dok se u profilaktičkoj terapiji koriste lijekovi iz skupina antihipertenziva, antidepresiva ili antiepileptika. Osim farmakoterapije, u liječenju odnosno prevenciji migrene mogu se koristiti komplementarne metode kao što su promjena životnih navika, biofeedback, akupunktura i transkutana električna stimulacija živaca.
Abstract (english) Migraine is a primary headache, whose prevalence in the general population of the European Union is 15%. It can be episodic but it can also be a chronic condition. It is characterized by a unilateral, pulsating headache and can last between 4 and 72 hours. Associated symptoms may include nausea, vomiting and sensitivity to light, sound or smell.
The direct and indirect annual costs of migraine are estimated to be 5 billion euros in the European Union. Thus, migraine is not only medical but also a socio-economic problem.
The exact cause of migraine headaches is unknown, but frequent positive family history indicates a connection with genetic factors. The central place in the pathogenesis of migraine belongs to the activation of the trigeminovascular system, with consequent vasodilatation and neurogenic inflammation of intracranial blood vessels that are innervated by C fibers from the trigeminal nerve.
The diagnosis of migraine should be based on clinical presentation and symptoms, and pursuant to the criteria set by the International Headache Society, it may be more closely classified as one of the types of migraine – migraine without aura and migraine with aura.
According to the European Federation of Neurological Societies, the treatment of migraine can be abortive - the removal and alleviation of symptoms, and prophylactic - prevention of the occurrence of symptoms. Non-steroidal anti-inflammatory drugs or triptans are used in the abortive therapy, and antihypertensive medication, antidepressants or antiepileptics are used in prophylactic therapy. In addition to pharmacotherapy, complementary methods, such as changing habits, biofeedback, acupuncture and transcutaneous electrical nerve stimulation, can also be used to treat or prevent migraine headache.
Keywords
migrena
patofiziologija
genetika
klinička slika
dijagnoza
terapija
Keywords (english)
migraine
pathophysiology
genetics
clinical features
diagnosis
treatment
Language croatian URN:NBN urn:nbn:hr:105:385671 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Repository Dr Med - University of Zagreb School of Medicine Digital Repository Created on 2017-08-23 07:59:44
