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undergraduate thesis
Priprema i karakterizacija kopulata ferocenoil klorida i timina
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. urn:nbn:hr:159:030564
Borko, Ana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Cite this document

Borko, A. (2015). Priprema i karakterizacija kopulata ferocenoil klorida i timina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:030564

Borko, Ana. "Priprema i karakterizacija kopulata ferocenoil klorida i timina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:030564

Borko, Ana. "Priprema i karakterizacija kopulata ferocenoil klorida i timina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:030564

Borko, A. (2015). 'Priprema i karakterizacija kopulata ferocenoil klorida i timina', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:159:030564

Borko A. Priprema i karakterizacija kopulata ferocenoil klorida i timina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2015 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:159:030564

A. Borko, "Priprema i karakterizacija kopulata ferocenoil klorida i timina", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:159:030564

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Metadata
TitlePriprema i karakterizacija kopulata ferocenoil klorida i timina
Title (english)Preparation and characterization of derivate fercenoil chlorid and thimine
AuthorAna Borko
MentorJasmina Lapić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2015-07-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
Imajući u vidu da nukleozidni analozi pokazuju značajnu biološku aktivnost, tj. da efikasno djeluju u sprječavanju razmnožavanja malignih stanica čiji je mehanizam djelovanja temeljen na mogućnosti ugradnje u rastući polinukleotidni lanac što uzrokuje prekid daljnje sinteze polinukleotida ili izmjenu funkcije novonastale nukleinske kiseline, u okviru ovog završnog rada višestupanjskom sintezom pripravljen je N1-ferocenoil timin 4. U literaturi je opisan niz ferocenilalkilnih derivata s nukeobazama koji su pokazali jako antitumorsko djelovanje prema karcinomu 755 [1]. Ferocenoilni derivati nukleobaza nisu opisani u literaturi te je sinteza ovog derivata vrlo zanimljiva u svrhu proučavanja kako biološke aktivnosti tako i elektrokemijskih svojstava pripravljenog biokonjugata.
Abstract (english)
Since nucleoside analogues show significant biological activity, ie. they efficienty act in inhibition of reproduction of malignant cells. That mechanism is based on installation capabilities in rising polynucleotide chain which result in inhibition of further synthesis of polynucleotide or exchange in function of newly created nucleic acid. In this final work, N1-ferrocenoil thimine 4 has been prepared by multistage synthesis. In literature it is described a row of ferrocenalkyl-nucleobase derivates which have shown strong antitumor activity against carcinoma 755 [1]. Ferrocenoil-nucleobase derivates were not described in literature so the synthesis of this analogue was interesting in order to study his biological activity and electrochemical properties.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:030564
Study programmeTitle: Food Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Food Technology and Biotechnology
Created on2017-04-25 12:15:10

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