Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke

Kačar, Dina

prikaz prve stranice dokumenta Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke

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undergraduate thesis

Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke

Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. urn:nbn:hr:159:173068

Kačar, Dina

University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

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APA 6th Edition

Kačar, D. (2014). Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:173068

MLA 8th Edition

Kačar, Dina. "Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:173068

Chicago 17th Edition

Harvard

Kačar, D. (2014). 'Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 16 April 2024, https://urn.nsk.hr/urn:nbn:hr:159:173068

Vancouver

Kačar D. Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2014 [cited 2024 April 16] Available at: https://urn.nsk.hr/urn:nbn:hr:159:173068

IEEE

D. Kačar, "Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:159:173068

Cite this item: https://urn.nsk.hr/urn:nbn:hr:159:173068

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Title	Procesi kancerogeneze, mehanizam djelovanja i regulacijska uloga miRNA-21, miRNA-26b i miRNA-10b u u karcinomu dojke
Title (english)	The process of carcinogenesis, mechanism and regulatory role of miRNA-21, miRNA-26B and miRNA-10b in breast cancer
Author	Dina Kačar
Mentor	Reno Hrašćan (mentor)
Granter	University of Zagreb Faculty of Food Technology and Biotechnology (Department of Biochemical Engineering) (Laboratory for Biology and Microbial Genetics) Zagreb
Defense date and country	2014-09-11, Croatia
Scientific / art field, discipline and subdiscipline	BIOTECHNICAL SCIENCES Biotechnology
Abstract	U radu je opisan razvoj tumora dojki kroz genetske aspekte kancerogeneze te promjene koje se javljaju tijekom tih procesa. Onkogeni imaju važnu ulogu u progresiji tumora i njihovom aktivacijom započinje proliferacija tumorskih stanica. Tumor supresijski geni imaju funkciju inhibiranja nastanka tumora i genetske promjene na tim genima su kritične tijekom kancerogeneze. Poseban naglasak u ovom radu je stavljen na regulaciju tumor supresijskih gena i onkogena na posttranskripcijskoj razini putem cirkularnih nekodirajućih microRNA molekula. Uvođenjem kemijski sintetiziranog oligonukleotida anti-miR-21 inhibira se rast tumora, a povećana ekspresija miR-26b u tumorskim stanicama ima suprimirajuće djelovanje na staničnu proliferaciju. Pokazalo se da prekomjerena ekspresija MiR-10b ima izrazito invazivno djelovanje i pozitivno regulira staničnu migraciju tijekom metastaziranja. Otkrićem njihove specifične regulacijske uloge, stabilne i visoko senzitivne miRNA mogu poslužiti kao minimalno invazivni biomarkeri u dijagnostici i prognostici karcinoma dojki te kao potencijalni terapeutici.
Abstract (english)	This paper describes the development of breast cancer through genetic aspects of carcinogenesis. Oncogenes play an important role in tumor progression and their activation enhance proliferation of tumor cells. The tumor suppression genes have the function of inhibiting tumors, therefore genetic alterations in these genes are critical during carcinogenesis. Emphasis in this study is placed on the regulation of tumor suppressor genes and oncogenes in the post-transcriptional level by circular non-coding microRNA molecules. The introduction of chemically synthesized oligonucleotides of anti-miR-21 inhibits the tumor growth, while the overexpression of miR-26b tumor cells has a suppressing effect on cell proliferation. It has been proved that overexpression of mir-10b has an extremely invasive activity and positively regulates cell migration during metastasis. The discovery of their specific regulatory role, stable and highly sensitive miRNA may serve as minimally invasive biomarkers in the diagnosis and prognosis of breast cancers as well as potential therapeutics.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:159:173068
Study programme	Title: Biotechnology Study programme type: university Study level: undergraduate Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resource	Text
File origin	Born digital
Access conditions	Access restricted to students and staff of home institution
Terms of use
Repository	Repository of the Faculty of Food Technology and Biotechnology
Created on	2017-04-26 12:46:26

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