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master's thesis
Nefroprotektivni učinak Ginkgo biloba u Y59 štakora
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. urn:nbn:hr:159:801141
Abramović, Iva
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Food Quality Control
Laboratory for Food Chemistry and Biochemistry

Cite this document

Abramović, I. (2014). Nefroprotektivni učinak Ginkgo biloba u Y59 štakora (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:801141

Abramović, Iva. "Nefroprotektivni učinak Ginkgo biloba u Y59 štakora." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:801141

Abramović, Iva. "Nefroprotektivni učinak Ginkgo biloba u Y59 štakora." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:801141

Abramović, I. (2014). 'Nefroprotektivni učinak Ginkgo biloba u Y59 štakora', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 25 April 2024, https://urn.nsk.hr/urn:nbn:hr:159:801141

Abramović I. Nefroprotektivni učinak Ginkgo biloba u Y59 štakora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2014 [cited 2024 April 25] Available at: https://urn.nsk.hr/urn:nbn:hr:159:801141

I. Abramović, "Nefroprotektivni učinak Ginkgo biloba u Y59 štakora", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:159:801141

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Metadata
TitleNefroprotektivni učinak Ginkgo biloba u Y59 štakora
Title (english)Nephroprotective effect of Ginkgo biloba in rats Y59
AuthorIva Abramović
MentorIrena Landeka Jurčević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Food Quality Control)
(Laboratory for Food Chemistry and Biochemistry)
Zagreb
Defense date and country2014-09-30, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Ginkgo biloba je biljka koja se, zbog svog širokog raspona ljekovitih i terapijskih svojstava, koristi kao alternativni lijek u liječenju brojnih indikacija. Smatra se da je temelj njenog terapijskog djelovanja visoka antioksidacijska aktivnost njenih spojeva. Starenje te okolišni i dijetetski ksenobiotici mogu uzrokovati nagomilavanje slobodnih radikala koji dovode do oksidacijskog stresa, oštećenja i smrti stanice. Bubrezi su izloženi nizu ksenobiotika koji mogu uzrokovati oksidacijska oštećenja. Cilj ovog istraživanja je bio ispitati nefroprotektivni učinak tri suplemenata Ginkgo bilobe tretiranjem štakora Y59 kroz 30 dana. Rezultati su pokazali statistički značajno (ANOVA, p<0.05) povećanje aktivnosti antioksidacijskih enzima SOD (superoksid dismutaza) i CAT (katalaza) te GSH (reduciranog glutationa) u bubrezima štakora tretiranih suplementima Ginkgo biloba i Ginkgo ALERT što ukazuje na njihov protektivni antioksidacijski efekt. Ovi dodaci prehrani su također značajno snizili koncentracije MDA (malondialdehida). Suprotan efekt je imao suplement Vulkan, biljni lijek za impotenciju koji je statistički značajno (ANOVA, p<0.05) smanjio aktivnost antioksidacijskih enzima i povećao koncentraciju MDA što ukazuje na oksidacijski stres.
Abstract (english)
Ginkgo biloba is an herb that is, due to its wide range of medicinal and therapeutic properties, used as an alternative medicine to treat numerous indications. It is considered that the foundation of its therapeutic effect is high antioxidant activity of its compounds. Aging and environmental and dietary xenobiotics can cause a buildup of free radicals that lead to oxidative stress, damage and cell death. Kidneys are exposed to a number of xenobiotics that can cause oxidative damage. The aim of this research was to investigate the possible nephroprotective effect of three Ginkgo biloba supplements in Y59 rats after treatment, which lasted for 30 days. The results showed statistically significant (ANOVA, p <0.05) increase in the activity of antioxidant enzymes SOD (superoxide dismutase) and CAT (catalase) and the concentration of GSH (reduced glutathione) in kidneys of rats treated with Ginkgo biloba and Ginkgo ALERT. It indicates their protective antioxidant effect. These supplements significantly decreased MDA levels (malondialdehyde). The opposite effect had supplement Vulkan, herbal medicine for impotence, which statistically significant (ANOVA, p <0.05) decreased activities of antioxidant enzymes and increased MDA concentrations indicating oxidative stress.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:801141
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Food Technology and Biotechnology
Created on2017-05-02 11:05:37

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