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master's thesis
Eksperimentalni sustav za identifikaciju proteina uključenih u stabilnost palidnroma u DNA
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. urn:nbn:hr:159:005847
Ivanković, Vanja
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Cite this document

Ivanković, V. (2012). Eksperimentalni sustav za identifikaciju proteina uključenih u stabilnost palidnroma u DNA (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:005847

Ivanković, Vanja. "Eksperimentalni sustav za identifikaciju proteina uključenih u stabilnost palidnroma u DNA." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:005847

Ivanković, Vanja. "Eksperimentalni sustav za identifikaciju proteina uključenih u stabilnost palidnroma u DNA." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2012. https://urn.nsk.hr/urn:nbn:hr:159:005847

Ivanković, V. (2012). 'Eksperimentalni sustav za identifikaciju proteina uključenih u stabilnost palidnroma u DNA', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:159:005847

Ivanković V. Eksperimentalni sustav za identifikaciju proteina uključenih u stabilnost palidnroma u DNA [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2012 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:159:005847

V. Ivanković, "Eksperimentalni sustav za identifikaciju proteina uključenih u stabilnost palidnroma u DNA", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:159:005847

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Metadata
TitleEksperimentalni sustav za identifikaciju proteina uključenih u stabilnost palidnroma u DNA
Title (english)Experimental systems for identification of proteins involved in stability of palindromes in DNA
AuthorVanja Ivanković
MentorIvan-Krešimir Svetec (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2012-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Palindromske sekvencije predstavljaju posebnu skupinu obrnutih ponavljanja koja nisu odijeljena niti jednim parom baza, a pronađene su u genomima svih organizama. Iako imaju važnu funkcionalnu ulogu u regulatornim dijelovima genoma kao što su promotori, terminatori i ishodišta replikacije, duži palindromi predstavljaju opasnost za stabilnost genoma budući da mogu tvoriti sekundarne strukture koje uzrokuju pucanje kromosoma te preraspodjelu genetičkog materijala, što može dovesti i do teških genetičkih bolesti kod ljudi. Pretpostavlja se da je nestabilnost palindroma posredovana cijelim nizom proteina, od kojih mnogi još uvijek nisu poznati. Zbog toga je cilj ovoga rada bio konstruirati eksperimentalni sustav za brzu i jednostavnu identifikaciju tih proteina, kako u genomu kvasca, tako i u humanom genomu. Primjena ovog sustava za identifikaciju nepoznatih proteina uključenih u (ne)stabilnost palindroma mogla bi unaprijediti buduća istraživanja genetičkih poremećaja potaknutih postojanjem palindroma u molekuli DNA.
Abstract (english)
Palindromic sequences represent a special group of inverted repeats that are not seperated by any base pairs, and are found in genomes of all organisms. Although they have important functional role in regulatory regions of genome such as promotors, terminators and replication initiation sites, longer palindromes represent danger for the genome stability due to their ability to form secondary structures that act as hotspots for chromosome breakage and genomic rearrangements, which can lead to severe genetic diseases in humans. It is believed that palindrome instability is mediated by an array of various proteins, many of which are still unknown. Therefore, the purpose of this thesis was developing an experimental system for quick and simple identification of those proteins in yeast, as well as in human genome. The usage of this system for identification of unknown proteins involved in palindrome (in)stability could improve future research of palindrome-mediated genetic disorders in DNA molecule.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:005847
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Food Technology and Biotechnology
Created on2017-05-09 07:29:18

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