Two-dimensional liquid chromatography directly connected with mass spectrometry was used in the analysis of the degradation products of torasemide produced by forced degradation. Torasemide samples were degraded under different conditions: 3 hours at 60⁰C, 24 hours at 105⁰C, with 1M HCl, 1M NaOH and 30% H2O2. Samples were analyzed by one-dimensional liquid chromatography, to verify that the decomposition occurred and that it was not exaggerated. They were then analysed by two-dimensional liquid chromatography directly connected with mass spectrometry. The chromatograms obtained after each dimension, as well as the mass spectra of the degradation products, were obtained. After samples were eluated from the first dimension, it was determined, by using obtained chromatograms, when the aliquots for analysis in the second dimension will be collected. The second dimension analysis showed the purity of the peaks after the first dimensional eluation and their sufficient separation. Then the mass spectrometry analysis followed. The degradation products were ionized by positive ionization mode and the ions were separated by the mass and charge ratio. The most common ions were again fragmented and their MS/MS spectra were obtained. Mass spectra of degradation products were compared with corresponding MS/MS spectra, and the structures of degradation products were drawn in the Chemdraw program. Torasemide degradation was the thorough in oxidizing conditions. By acid and basic hydrolysis, the degradation product of mass 264.08 is formed. Its presence was confirmed in all samples. That is the most significant degradation product, and is among the specified impurities of torasemide in the European Pharmacopoeia. By means of the drawn structures, pathways of degradation of torasemide were assumed under different stress conditions.