Praćenje antiagregacijske terapije metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500

Kuktić, Ivona

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master's thesis

Praćenje antiagregacijske terapije metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500

Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2018. urn:nbn:hr:163:364540

Kuktić, Ivona

University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of biochemistry and molecular biology

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APA 6th Edition

Kuktić, I. (2018). Praćenje antiagregacijske terapije metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500 (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:364540

MLA 8th Edition

Kuktić, Ivona. "Praćenje antiagregacijske terapije metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:163:364540

Chicago 17th Edition

Harvard

Kuktić, I. (2018). 'Praćenje antiagregacijske terapije metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 January 2025, https://urn.nsk.hr/urn:nbn:hr:163:364540

Vancouver

Kuktić I. Praćenje antiagregacijske terapije metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500 [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2018 [cited 2025 January 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:364540

IEEE

I. Kuktić, "Praćenje antiagregacijske terapije metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:163:364540

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:364540

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Title	Praćenje antiagregacijske terapije metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500
Title (english)	Monitoring of antiplatelet therapy by optical aggregometry on Sysmex CS-2500 analytical system
Author	Ivona Kuktić
Mentor	Sandra Šupraha Goreta (mentor)
Mentor	Sandra Margetić (mentor)
Committee member	Sandra Šupraha Goreta (predsjednik povjerenstva)
Committee member	Nada Vrkić (član povjerenstva)
Committee member	Sandra Margetić (član povjerenstva)
Granter	University of Zagreb Faculty of Pharmacy and Biochemistry (Department of biochemistry and molecular biology) Zagreb
Defense date and country	2018-09-18, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Abstract	Antiagregacijski (antitrombocitni) lijekovi posljednih se godina sve češće koriste u prevenciji i liječenju arterijske tromboze koja se klinički očituje akutnim ishemijskim dogaĎajima. Kontinuirani porast primjene ovih lijekova nametnuo je potrebu za uvoĎenjem agregometrije trombocita u procjeni učinkovitosti liječenja. Iako ove pretrage još uvijek nisu sastavni dio rutinske laboratorijske dijagnostike zbog nedovoljne standardizacije, očita je potreba za njezinim uvoĎenjem u praćenju liječenja ovih bolesnika. Cilj ovog rada bio je ispitati utjecaj antiagregacijskih lijekova na agregabilnost trombocita uz primjenu specifičnih agonista za pojedinu skupinu lijekova (acetilsalicilna kiselina (ASA) i/ili inhibitori ADP receptora) metodom optičke agregometrije na analitičkom sustavu Sysmex CS-2500. Agregabilnost trombocita bila je značajno snižena za obe skupine antiagregacijskih lijekova u odnosu na referentne vrijednosti. U bolesnika kod kojih je antiagregacijska terapija ukinuta zbog operativnog zahvata, oporavak funkcije trombocita postiže se brže u bolesnika liječenih ASA-om, u odnosu na bolesnike liječene inhibitorom ADP receptora ili kombiniranom terapijom.
Abstract (english)	In recent years inhibitors of platelet aggregation (antiplatelet drugs) are increasingly used in the prevention and treatment of arterial thrombosis that is clinically manifested by acute ischemic events. Continued increase in the use of these drugs has imposed the need for introducing platelet aggregometry to assess the efficiency of treatment. Although these assays still are not a part of routine laboratory diagnostics due to insufficient standardization, the need for its introduction in treatment of these patients is apparent. The aim of this study was to investigate the effect of antiplatelet drugs on platelet aggregation using specific agonists for particular drug group (acetylsalicylic acid (ASA) and /or ADP receptor inhibitors) by light transmission aggregometry method on the Sysmex CS 2500 analytical system. Platelet aggregation was significantly reduced for both groups of antiplatelet drugs compared to the reference values. In patients with antiplatelet therapy abolished due to surgery, recovery of platelet function was achieved faster in patients treated with ASA compared to patients treated with inhibitors of ADP receptors or those with combined therapy.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:163:364540
Study programme	Title: Medical biochemistry Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: magistar/magistra medicinske biokemije (magistar/magistra medicinske biokemije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
Created on	2019-04-12 09:44:48