Isolation of bioactive metabolites from the red alga Sphaerococcus coronopifolius

Tomić, Anamarija

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master's thesis

Isolation of bioactive metabolites from the red alga Sphaerococcus coronopifolius

Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. urn:nbn:hr:163:765070

Tomić, Anamarija

University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacognosy

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APA 6th Edition

Tomić, A. (2015). Isolation of bioactive metabolites from the red alga Sphaerococcus coronopifolius (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:765070

MLA 8th Edition

Tomić, Anamarija. "Isolation of bioactive metabolites from the red alga Sphaerococcus coronopifolius." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. https://urn.nsk.hr/urn:nbn:hr:163:765070

Chicago 17th Edition

Harvard

Tomić, A. (2015). 'Isolation of bioactive metabolites from the red alga Sphaerococcus coronopifolius', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 20 January 2025, https://urn.nsk.hr/urn:nbn:hr:163:765070

Vancouver

Tomić A. Isolation of bioactive metabolites from the red alga Sphaerococcus coronopifolius [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2015 [cited 2025 January 20] Available at: https://urn.nsk.hr/urn:nbn:hr:163:765070

IEEE

A. Tomić, "Isolation of bioactive metabolites from the red alga Sphaerococcus coronopifolius", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:163:765070

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:765070

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Metadata

Title	Isolation of bioactive metabolites from the red alga Sphaerococcus coronopifolius
Author	Anamarija Tomić
Mentor	Marijana Zovko Končić (mentor)
Committee member	Marijana Zovko Končić
Committee member	Lidija Bach-Rojecky
Committee member	Jasna Jablan
Granter	University of Zagreb Faculty of Pharmacy and Biochemistry (Department of pharmacognosy) Zagreb
Defense date and country	2015-12-22, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Abstract	Kada govorimo o izolaciji bioaktivnih metabolita i komponenti za različite medicinske svrhe, morski organizmi su godinama nedovoljno istraživani u odnosu na većinu kopnenih biljaka. U proteklih nekoliko desetljeća otkad su znanstvenici počeli više istraživati morski okoliš, otkrili su bogatstvo morskih metabolita za široki spektar primjene. Crvena alga Sphaerococcus coronopifolius je morska biljka koja je i ranije često istraživana zbog svojeg kemijskog sastava. Mnogi od njenih izoliranih spojeva, koji spadaju u skupinu bromoditerpena, su pokazali antitumorski i antimikrobni učinak. Ta otkrića su dobra motivacija za znanstvenike da nastave istraživati ovu crvenu algu. Cilj ovog diplomskog rada je bio izolirati i identificirati bioaktivne komponente crvene alge S. coronopifolius. Izolacija bioaktivnih komponenti S. coronopifolius počela je vakuum tekućinskom kromatografijom na početnom organskom ekstraktu, što je rezultiralo većim brojem frakcija. Prva od spomenutih frakcija je identificirana kao allo-aromadendren. Četvrta frakcija je podvrgnuta HPLC analizi, što je rezultiralo izolacijom dviju čistih bioaktivnih komponenti identificiranih kao bromosferol i sferokocenol A.
Abstract (english)	For many years marine organisms have been underinvestigated when compared to most terrestrial plants regarding the isolation of their metabolites and their evaluation for different medical purposes. In last couple of decades that scientists turned their attention on the marine environment, they disovered wealth of marine metabolites for a wide array of applications. The red alga Sphaerococcus coronopifolius is marine plant that has been investigated in the past for its chemistry. Many of its isolated compounds which belong in group of bromoditerpenes showed antitumor and antimicrobial effects. Those discoveries are good motivation for scientists to continue exploring this red alga. The main objective of this diploma thesis was to isolate and identify bioactive compounds of red alga S. coronopifolius. The isolation of the bioactive compounds from S. cornopifolius started with vacuum liquid chromatography of the initial organic extract, which yielded a number of fractions. The first of these fractions was identified as allo-aromadendrene. The fourth fraction was objected to HPLC analyses, which resulted in the isolation of two pure compounds identified as bromosphaerol and sphaerococcenol A.
Keywords
Keywords (english)
Language	english
URN:NBN	urn:nbn:hr:163:765070
Study programme	Title: Pharmacy Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
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Repository	Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
Created on	2016-02-25 12:53:37