Nanocrystal technology is intensely being developed and with its application in the pharmaceutical industry, the biopharmaceutical and pharmaceutical-technological properties of active ingredients are trying to be improved. Nanocrystals are particles with size from 1 to 1000 nm and they increase the dissolution rate by increasing the specific surface area. The method of nanocrystal production depends on the physicochemical nature of the active ingredient, but the two main groups of methods are methods that decrease the particle size (top-down methods) and methods that increase the particle size (bottom-up methods). The complexity of the eye structure presents as the limit for the drug delivery and formulations based on nanocrystals have shown themselves successful in achieving increased retention time, bioavailability and drug permeability through barriers of the eye. For the dry eye treatment a 2% rebamipide suspension is available on the market which after its application causes short-term blurred vision because of its milky-white appearance. In this study rebamipide nanosuspensions have been made with the addition of surfactants Polisorbate 80 and Pluronic F-68 in different ratios. The nanosuspensions were made using the wet grinding method and the particle size, polydispersity index and proportion of the crystalline fraction of the drug were measured. From the collected results it was concluded that the best results were accomplished in nanosuspensions that contained 0.25% and 0.5% of surfactants. The appearance of the nanosuspension remained milky-white despite the fact that in all samples the particle size was lesser than 400 nm.