Lipid droplets in models of Parkinson's and stroke

Sabol, Leo

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master's thesis

Lipid droplets in models of Parkinson's and stroke

Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. urn:nbn:hr:163:831460

Sabol, Leo

University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

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APA 6th Edition

Sabol, L. (2021). Lipid droplets in models of Parkinson's and stroke (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:831460

MLA 8th Edition

Sabol, Leo. "Lipid droplets in models of Parkinson's and stroke." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:831460

Chicago 17th Edition

Sabol, Leo. "Lipid droplets in models of Parkinson's and stroke." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:831460

Harvard

Sabol, L. (2021). 'Lipid droplets in models of Parkinson's and stroke', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 26 January 2025, https://urn.nsk.hr/urn:nbn:hr:163:831460

Vancouver

Sabol L. Lipid droplets in models of Parkinson's and stroke [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2021 [cited 2025 January 26] Available at: https://urn.nsk.hr/urn:nbn:hr:163:831460

IEEE

L. Sabol, "Lipid droplets in models of Parkinson's and stroke", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:163:831460

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:831460

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Metadata

Title	Lipid droplets in models of Parkinson's and stroke
Title (croatian)	Lipidne kapljice u modelima Parkinsonove bolesti i moždanog udara
Author	Leo Sabol
Mentor	Lidija Bach-Rojecky (mentor)
Committee member	Lidija Bach-Rojecky (predsjednik povjerenstva)
Committee member	Ana-Marija Domijan (član povjerenstva)
Committee member	Sandra Šupraha Goreta (član povjerenstva)
Granter	University of Zagreb Faculty of Pharmacy and Biochemistry (Department of pharmacology) Zagreb
Defense date and country	2021-09-16, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Abstract	Parkinson’s disease presents a great challenge in diagnose and treatment, as does stroke. Both require attention to improve these treatments and survivability. Somewhat new and uncharted territory in brain are lipid droplets. They are storage organelles as the pillar of lipid and energy homeostasis, but their function in brain is not yet absolutely defined and it could be of great influence. Goal of this thesis is to positively identify lipid droplets as active participants in neuroinflammation process regarding ischemic stroke and Parkinson’s disease using 6-OHDA models for Parkinson’s and three-vessel occlusion samples for ischemic stroke. Additionally, lipid droplets as participants in neuroinflammation are being identified in thapsigargin treated BV2 cells.
Abstract (english)	Parkinsonova bolest, kao i moždani udar, predstavlja ogromni problem kod dijagnostociranja i liječenja. Oba stanja zahtijevaju trenutnu pažnju za unaprijeđenje liječenja i smanjenje smrtnosti. Jedno od nedovoljno istraženih i novih dijelova tih bolesti su lipidne kapljice. One su, kao lipidni organeli, temeljni stupovi lipidne i energetske homeostaze, no njihova cjelovita uloga u mozgu nije još definirana i mogla bi biti od velikog značenja. Cilj ovog rada je sa sigurnošću identificirati lipidne kapljice kao aktivne sudionike upalnog procesa u mozgu tijekom Parkinsonove bolesti i ishemičnog moždanog udara koristeći modele 6-hidroksidopamina za Parkinsonovu bolest i uzorke sa trožilnom okluzijom za ishemični moždani udar. Također, identifikacija lipidnih kapljica kao aktivnih sudionika upalnih procesa u mozgu vrši se koristeći BV2 stanične culture tretirane s tapsigarginom.
Keywords
Keywords (english)
Language	english
URN:NBN	urn:nbn:hr:163:831460
Study programme	Title: Pharmacy Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
Created on	2022-02-08 13:41:48