Hashimoto's thyroiditis (HT) is an organ-specific autoimmune disease characterized by chronic inflammation of the thyroid gland with lymphocytic tissue infiltration and serum positive thyroid autoantibodies. For optimal thyroid function, emphasis is set on specific micronutrients; iodine, selenium, iron and vitamin D, with increasing number of studies regarding their role in etiology, prevention and treatment of HT. Application of different dietary models has also been investigated, although there are still no official guidelines for nutritional support in HT patients. The aim of this literature review is to give a systematic overview of the latest research results on possibilities of nutritional intervention in patients with HT and to evaluate them as a justified complementary strategy for the prevention and treatment of hypothyroidism caused by HT and HT itself. Methods included a review of the available scientific literature on the influence of vitamin/mineral supplementation and nutrition on the development of HT and its comorbidities. Occurrence of significant food/dietary supplements - levothyroxine interactions, and significance of the intestinal microbiota on disease development and course were also investigated. Tailored micronutrient supplementation for the correction of proven micronutritive deficiencies, as well as probiotic supplementation for the prevention or treatment of intestinal dysbiosis in patients with HT was justified. The recommendation of time-separate administration of levothyroxine and food / dietary supplements to prevent clinically significant interactions that reduce drug absorption and effectiveness was confirmed. The most promising and justified nutritional intervention is Mediterranean diet, due to high patient adherence and proven benefits in the prevention and support in treatment of HT and its comorbidities. Application of other nutritional interventions such as vegan / vegetarian diet, and various elimination diets (gluten-free, low FODMAP diet, LCHF / ketogenic, Paleo diet, autoimmune protocol) was found to be only partially justified. When recommending elimination diet, emphasis should be set on comprehensive individual counselling of HT patient, and conduction of therapy under strict expert supervision. Nutritional interventions in HT patients should be implemented by a multidisciplinary team (physician, dietitian, pharmacist, psychologist) and nutrition counselling should be encouraged in clinical practice. Hypothesis that the application of specific dietary patterns and targeted individual supplementation can contribute to the prevention or alleviation of symptoms of HT, hypothyroidism caused by HT and the symptoms of the most common secondary comorbidities was confirmed.