Urinary tract infections are recurrent when they occur at least three times in a year or two times in six months. Goal of this paper was to present the most relevant guidelines in treatment and prevention of this increasingly common health problem. Special emphasis was placed on the role of the pharmacist as the pharmacist is the most accessible health professional. The most common therapy for the treatment of acute and prevention of recurrent infections is antimicrobial, and the pharmacist, understanding the therapy prescribed by the doctor, has a wealth of knowledge about adjuvant therapy, non-antimicrobial preparations and non-pharmacological measures. It is necessary to distinguish between nonantimicrobial preparations that are used for a short time in the treatment of acute infections and others that are used over a long period of time in prevention. The most famous in the treatment of acute infections is certainly the bearberry leaf, which is considered a traditional herbal medicine. On the other hand, D-mannose has very strong evidence for prevention, comparable even to antimicrobial prophylaxis. Cranberry, N-acetylcysteine, probiotics (Lactobacillus spp.), Vaccines, hormone replacement therapy and glycosaminoglycans also have evidence. Urinary tract infections are common in pregnant women, and in these situations asymptomatic bacteriuria is treated, primarily with beta-lactam antibiotics, and in prevention it is advisable to use cranberries. An additional problem in preventing recurrent infections is bacterial resistance that grows from year to year. It is comforting that nitrofurantoin as first-line in treatment and prevention has not yet developed clinically significant resistance. The role of the pharmacist is extremely important in prevention and treatment counseling. The pharmacist has knowledge of pharmacological therapy, but also of herbal preparations and other dietary supplements. It is crucial to identify situations in which self-treatment of urinary tract infections is not recommended. Those patients need to be referred to a doctor.