Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena

Koraj, Natan

prikaz prve stranice dokumenta Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena

Download
PDF 2.39 MB

master's thesis

Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena

Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. urn:nbn:hr:163:826086

Koraj, Natan

University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Cite this document

APA 6th Edition

Koraj, N. (2022). Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:826086

MLA 8th Edition

Koraj, Natan. "Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:163:826086

Chicago 17th Edition

Harvard

Koraj, N. (2022). 'Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 23 January 2025, https://urn.nsk.hr/urn:nbn:hr:163:826086

Vancouver

Koraj N. Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2022 [cited 2025 January 23] Available at: https://urn.nsk.hr/urn:nbn:hr:163:826086

IEEE

N. Koraj, "Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:163:826086

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:826086

Please login to the repository to save this object to your list.

Metadata

Title	Sinteza i karakterizacija harmicena; novih 1-, 7- i 9-supstituiranih amida β-karbolina i ferocena
Title (english)	Synthesis and characterisation of harmicens; novel 1-, 7- and 9- supstituted amides of β-carboline and ferrocene
Author	Natan Koraj
Mentor	Ivana Perković (mentor)
Committee member	Ivana Perković (predsjednik povjerenstva)
Committee member	Kristina Pavić (član povjerenstva)
Committee member	Miranda Sertić (član povjerenstva)
Granter	University of Zagreb Faculty of Pharmacy and Biochemistry (Department of medicinal chemistry) Zagreb
Defense date and country	2022-07-11, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Abstract	Ovaj rad obuhvaća sintezu i karakterizaciju harmicena – hibridnih spojeva β-karbolina i ferocena. U ovom radu sintetizirana su tri nova 1-, 7- i 9- supstituirana amida 4a-c. Amino derivat β-karbolina 1f, potreban za sintezu amida 4a dobiven je iz triptamina, a amini 2c i 3b, koji su poslužili kao prekursori za sintezu amida 4b i 4c, dobiveni su iz harmina prema navedenoj shemi. U posljednjem koraku u 'coupling' reakciji ferocenkarboksilne kiseline i odgovarajućeg amina dobiveni su konačni spojevi – hibridi amidnog tipa 4a-c. Konačni hibridni spojevi karakterizirani su uobičajenim analitičkim i spektroskopskim metodama (IR, MS, 1H i 13C NMR), a čvrstim produktima određeno je talište. Antimalarijsko djelovanje novih spojeva na eritrocitnu fazu P. falciparum (Pf3D7 i PfDd2) i na jetrenu fazu P. berghei biti će ispitano u daljnjim istraživanjima.
Abstract (english)	This work contains the synthesis and characterisation of harmicenes – hybrid compounds of β-carboline and ferrocene. In this work three novel 1-. 7- and 9- supstituted amides 4a-c were synthetised. The amino derivative of β-carboline 1f, used for the synthesis of the amide 4a, was prepared from triptamine, and the amines 2c and 3b, that served as precursors in the synthesis of the amides 4b and 4c, were prepared from harmine according to the presented scheme. The final amide type hybrids 4a-c were obtained via a coupling reaction of ferrocenecarboxylic acid and the corresponding β-carboline amine. The final hybrid products were characterized using conventional spectroscopic methods (IR, 1H and 13C NMR and MS), and their melting points were determined. Further studies will investigate antimalarial activity of the derivatives against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2) and liver stage of P. berghei.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:163:826086
Study programme	Title: Pharmacy Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access Embargo expiration date: 2023-07-11
Terms of use
Repository	Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
Created on	2022-07-27 15:04:55