Objectives: This study aimed to explore the prevalence and nature of pharmacists’ interventions conducted in the routine practice in community pharmacies setting in Croatia, related to the use of medications. Subjects and methods: The study was conducted as observational, cross-sectional study with 71 volunteer participants. The data was anonymously collected via online survey developed for the purpose of this research. The survey consisted of two questionnaires, one referring to general information of pharmacist and community pharmacy he/she is employed in, and the other questionnaire based of PCNE V9.1 (Pharmaceutical Care Network Europe) classification of drug-related problems. Participants were documenting all recognized drug related problems and conducted interventions via online survey during a period of three consecutive days. Participants who did not have any intervention during the three-day period were asked to report that in the survey. All collected data was statistically analyzed. Results: There were in total 152 conducted interventions by 71 pharmacists. Average number of conducted interventions during a three-day period was 2,14 (1,70), ranging from 0 to 7. Most participants (53,5%) had 1 or 2 interventions with median of duration of intervention being 6 minutes. This research did not find statistically significant relationship between characteristics of pharmacist or community pharmacies and number of conducted interventions. There are indications that interventions conducted on a prescriber/physician level were potentially more time-consuming and had higher rates of completely solved drugrelated problems (83,3%), compared to interventions which didn't include intervening on prescriber/physician level (52,2%). Interventions suggested by participants during this research had a rate of 64,5% completely solved drug-related problems, 90,8% of interventions were accepted and all but one were rated as valid. Conclusion: This research showed that community pharmacists intervene on an every-day basis. That way they contribute to solving and prevention of drug-related problems, ensuring safe and efficient drug therapy. In order to successfully solve drug-related problems, it’s important to include prescriber/physician in solving of drug-related problems, showing a recognized need to ensure efficient way of communication between pharmacists and physicians. High percentage of valid and accepted interventions imply that study participants have necessary skills to successfully conduct interventions in order to solve and prevent drugrelated problems and to provide pharmaceutical care.