Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima

Jagodić, Lucija

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master's thesis

Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima

Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:646536

Jagodić, Lucija

University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Cite this document

APA 6th Edition

Jagodić, L. (2024). Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:646536

MLA 8th Edition

Jagodić, Lucija. "Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:646536

Chicago 17th Edition

Harvard

Jagodić, L. (2024). 'Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 January 2025, https://urn.nsk.hr/urn:nbn:hr:163:646536

Vancouver

Jagodić L. Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2025 January 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:646536

IEEE

L. Jagodić, "Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:646536

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:646536

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Metadata

Title	Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima
Title (english)	Novel pharmacotherapy possibilities for treatment of infections caused by ESKAPE pathogens
Author	Lucija Jagodić
Mentor	Petra Turčić (mentor)
Committee member	Petra Turčić (predsjednik povjerenstva)
Committee member	Maja Ortner Hadžiabdić (član povjerenstva)
Committee member	Ivana Perković (član povjerenstva)
Granter	University of Zagreb Faculty of Pharmacy and Biochemistry (Department of pharmacology) Zagreb
Defense date and country	2024-03-19, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Abstract	Antibiotici su nam godinama služili kao dragocjeno oružje u borbi s bakterijskim infekcijama i u današnje doba teško je zamisliti život bez njih. Visoka učestalost višestrukorezistentnih sojeva bakterija, s naglaskom na patogene okrunjene akronimom ESKAPE, i otežan razvoj novih antibiotika značajno ograničavaju mogućnosti u terapiji bakterijskih infekcija i često dovode do nepovoljnih kliničkih ishoda. Osim zbog neadekvatne mogućnosti osiguranja zdravlja različitih skupina pacijenata, ove su infekcije i financijski teret za zdravstvo. Problem je prisutan na globalnoj razini i nužno je što brže djelovanje u razvoju lijekova s drukčijim mehanizmima djelovanja. Pojava višestrukorezistentnih sojeva predstavlja veliku opasnost u zdravstvenom sustavu, što se posebice odnosi na pacijente već narušenog zdravlja koji ovakve infekcije najčešće steknu boravkom u ustanovama povezanim sa zdravstvenom skrbi. Kako bismo si osigurali dovoljno vremena za istraživanje novih terapijskih opcija za sprječavanje i liječenje bakterijskih infekcija, moramo se fokusirati na očuvanje učinkovitosti postojećih antibiotika. Iako mnoge alternative antibioticima pokazuju potencijal u rješavanju gorućeg problema antimikrobne rezistencije, u ovom trenutku i dalje nemamo ništa konkretno, stoga nam ne preostaje ništa osim ulagati više napora u bazična i klinička istraživanja
Abstract (english)	For decades antibiotics have served as a valuable weapon in the fight against bacterial infections which is why it is impossible to imagine a world without them. However, increasing incidence of MDR strains, especially pathogens summarised by acronym ESKAPE, along with challenges in development of new antibiotics, all contribute to significant limitations in antimicrobial therapies which often result in unwanted clinical outcomes. Besides inadequate care for various groups of patients, these infections act as a financial burden to healthcare systems. The problem is present across the globe and it is important to act quicker when it comes to development of new drugs with different acting mechanisms. The MDR phenomenon presents a serious threat to healthcare systems, which is particularly important for patients with pre-existing comorbidity who are usually the most prone to these types of pathogens by residing in various health care facilities. Although alternatives to antibiotics demonstrate some potential in resolving antimicrobial resistance, we do not have a conclusive solution which is why it is important to invest more effort into basic and clinical trials.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:163:646536
Study programme	Title: Pharmacy - integrated undergraduate and graduate - university study Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
Created on	2024-05-23 14:06:05