Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka

Novaković, Ivan

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master's thesis

Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka

Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2017. urn:nbn:hr:163:999879

Novaković, Ivan

University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

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APA 6th Edition

Novaković, I. (2017). Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:999879

MLA 8th Edition

Novaković, Ivan. "Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:163:999879

Chicago 17th Edition

Harvard

Novaković, I. (2017). 'Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 18 January 2025, https://urn.nsk.hr/urn:nbn:hr:163:999879

Vancouver

Novaković I. Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2017 [cited 2025 January 18] Available at: https://urn.nsk.hr/urn:nbn:hr:163:999879

IEEE

I. Novaković, "Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:163:999879

Cite this item: https://urn.nsk.hr/urn:nbn:hr:163:999879

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Title	Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka
Title (english)	Determination of antiaggregatory effect of ethanolic extracts of lemonbalm leaves
Author	Ivan Novaković
Mentor	Mirza Bojić (mentor)
Committee member	Mirza Bojić (predsjednik povjerenstva)
Committee member	Željan Maleš (član povjerenstva)
Committee member	Miranda Sertić (član povjerenstva)
Granter	University of Zagreb Faculty of Pharmacy and Biochemistry (Department of medicinal chemistry) Zagreb
Defense date and country	2017-05-02, Croatia
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Abstract	Kardiovaskularne bolesti uzimaju sve više života i povećavaju teret zdravstvenih sustava. Pacijenti s poviješću tromboembolijskih poremećaja moraju dulje vremena, a nekad i doživotno uzimati antiagregacijsku terapiju koja uzrokuje raznovrsne nuspojave. Sigurna i učinkovita farmakoterapija tromboembolijskih bolesti jedan je od važnih ciljeva farmaceutske struke čijim bi se ostvarenjem postiglo i smanjenje potrošnje zdravstvenih sustava. Polifenoli, posebice flavonoidi, su spojevi koji se nalaze u biljkama i koji posebno obećavaju kad su u pitanju prevencija i terapija raznih kardiovaskularnih pa tako i tromboembolijskih bolesti. Matičnjak je mediteranska biljka s dugo poznatim blagotvornim svojstvima. U ovome radu proučavao se antiagregacijski učinak etanolnog ekstrakta lista matičnjaka, a metoda koja se koristila je trombocitna impedancijska agregometrija. Nakon podvrgavanja dobivenih rezultata statističkoj analizi zaključuje se da ekstrakt matičnjaka ima zamjetno antiagregacijsko djelovanje koje bi se moglo iskoristiti za daljnja istraživanja koja su potrebna kako bi se u potpunosti razumjelo na koji se način događa inhibicija agregacije i kako bi se našao način da se ove spoznaje potencijalno primjene u farmakoterapiji tromboembolijskih bolesti.
Abstract (english)	Cardiovascular diseases take the increasing nuber of lives and increase the burden on healthcare systems. Patients with history of thromboembolic disorders must take antiaggregatory therapy for extended periods of time and sometimes for life. That therapy can cause various side effects. Safe and efficient pharmacotherapy of the thromboembolic disorders is one of the important goals of pharmacy which, if achieved, would lead to decrease of expenditure in healthcare. Polyphenols and especially flavonoids are compounds found in plants which show the most promise when prevention and therapy of various cardiovascular diseases and therefore thromboembolic disorders is considered. Lemonbalm is mediterranean plant with long known beneficial properties. This thesis studies the antiaggregatory effect of ethanolic extract of lemonbalm leaves. The method used to measure that effect was impedance aggregometry. After statistical analysis of the results it can be concluded that lemonbalm extract does have a notable antiaggregatory properties that should be examined further in the future research which is neccessary to gain a full understanding of the mechanism in which the inhibition of aggregation takes place and to find a suitable way in which these findings could be used in the pharmacotherapy of thromboembolic disorders.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:163:999879
Study programme	Title: Pharmacy Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
Created on	2017-11-29 11:34:28