prikaz prve stranice dokumenta Tumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora
  Download
PDF 1.03 MB
undergraduate thesis
Tumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:349353
Jurić, Vanja
University of Zagreb
Faculty of Science
Department of Biology

Cite this document

Jurić, V. (2017). Tumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:349353

Jurić, Vanja. "Tumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora." Undergraduate thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:349353

Jurić, Vanja. "Tumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora." Undergraduate thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:349353

Jurić, V. (2017). 'Tumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 24 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:349353

Jurić V. Tumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 April 24] Available at: https://urn.nsk.hr/urn:nbn:hr:217:349353

V. Jurić, "Tumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:349353

Please login to the repository to save this object to your list.
Metadata
TitleTumor supresorski geni i mehanizmi popravka oštećene DNA u stanicama tumora
Title (english)Tumor supressor genes and mechanisms of DNA repair in tumor cells
AuthorVanja Jurić
MentorNada Oršolić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2017-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Tumor supresori su geni koji štite stanice od progresije do tumora, a njihove mutacije, odnosno inaktivacije mogu uzrokovati razvoj tumora. Tumor supresori, odnosno njihovi proteinski produkti, imaju različite učinke na stanični ciklus: utišavaju gene važne za nastavak staničnog ciklusa i tako inhibiraju staničnu diobu, odgovaraju na signale oštećene DNA i povezuju ih sa staničnim ciklusom, stimuliraju apoptozu te inhibiraju metastazu. Tumor supresori sudjeluju u popravku DNA na način da promoviraju ili suprimiraju određeni mehanizam popravka DNA, kao što to rade p53 i PTEN, ali proteinski produkti tumor supresora ponekad mogu i izravno sudjelovati u popravku DNA, što je vidljivo kod proteina BRCA1 i BRCA2.
Abstract (english)
Tumor suppressors are genes involved in protecting cells from developing into tumors, and mutations of those genes, or more precisely, the inactivation of those genes, can stimulate tumor development. Tumor suppressors, or to be more specific, their protein products, have diverse effects on the cell cycle: they repress genes essential in the continuing of the cell cycle and therefore inhibit cell division, respond to DNA damage signals and couple them with the cell cycle, promote apoptosis and inhibit metastasis. Tumor suppressors are also involved in DNA repair mechanisms, either by promoting or suppressing specific repair mechanisms, which can be observed with p53 and PTEN, or by direct involvement of the tumor suppressor proteins in DNA repair, with the best examples being BRCA1 and BRCA2.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:349353
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Science
Created on2017-10-19 08:16:47

(©) Nacionalna i sveučilišna knjižnica u Zagrebu 2015. Sva prava pridržana. | Hrvatske bratske zajednice 4 p.p. 550, 10000 Zagreb, Hrvatska Tel. ++ 385 1 616-4040
OIB: 84838770814 | IBAN: HR66 2340 0091 1000 1008 1, Porezni broj (PDV identifikacijski broj) - VAT Number: HR84838770814
Prijava u repozitorij