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undergraduate thesis
Katalitička antitijela
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:596847
Žužić, Lorena
University of Zagreb
Faculty of Science
Department of Biology

Cite this document

Žužić, L. (2014). Katalitička antitijela (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:596847

Žužić, Lorena. "Katalitička antitijela." Undergraduate thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:596847

Žužić, Lorena. "Katalitička antitijela." Undergraduate thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:596847

Žužić, L. (2014). 'Katalitička antitijela', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 19 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:596847

Žužić L. Katalitička antitijela [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 April 19] Available at: https://urn.nsk.hr/urn:nbn:hr:217:596847

L. Žužić, "Katalitička antitijela", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:596847

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Metadata
TitleKatalitička antitijela
Title (english)Catalytic antibodies
AuthorLorena Žužić
MentorIta Gruić Sovulj (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Katalitička antitijela ili abzimi su imunoglobulini s vlastitom katalitičkom aktivnošću. Kako bi se dobila antitijela sa svojstvima katalizatora, kao imunogeni koriste se hapteni koji nalikuju na prijelazno stanje željene reakcije. Katalitička antitijela mogu se dizajnirati za širok spektar kemijskih transformacija i uključuju katalizatore koji pokazuju visok stupanj stereoselektivnosti, one koje koriste nekonvencionalne kofaktore te antitijela koja kataliziraju procese za koje ne postoje prirodni enzimi. Unatoč velikim mogućnostima njihove primjene na području biokemije, organske kemije, biotehnologije ili medicine, visoki troškovi, dugotrajnost postupka proizvodnje i slabija katalitička efikasnost predstavljaju veliku prepreku za njihov daljnji razvoj. Nova perspektiva za katalitička antitijela pojavljuje se na području medicine gdje se abzimi koriste kao terapeutici u detoksifikaciji i liječenju tumora.
Abstract (english)
Catalytic antibodies or abzymes are immunoglobulins with intrinsic catalytic properties. In order to obtain such antibodies, haptens which resemble the transition state of a given reaction are used as immunogens. Catalytic antibodies can be generated for a wide spectrum of chemical transformations – they include catalysts which show great level of stereoselectivity, those which utilize unusual cofactors, as well as antibodies that are able to catalyze reactions for which natural enzymes have yet to be found. Applications of antibody catalysis in biochemistry, organic chemistry, biotechnology and medicine are numerous, however, high costs, slow production and modest catalytic efficiency pose great limitations in further advancement of this technology. New perspective for catalytic antibodies arises from the field of medicine as they are being used as therapeutics in detoxification and cancer treatment.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:596847
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Science
Created on2017-12-12 09:14:13

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