Data about the toxicity of plants are important for botany, pharmacy, veterinary medicine, medicine, etc. Despite the fact that the sources of information about toxic plants are numerous, cumulative views for Croatia are scarce and incomplete. The largest part of compiled data is collected in the database Flora Croatica - Useful plants, but updates are possible and necessary. Data analysis using the FCD web sites showed that the total number of reported toxic species in the flora of Croatia is 553 of a total of 1193 species that have documented the economic use. Toxicity data contained in the Lewis et al. (2007) were analyzed, transformed into a supported standard for FCD-economic botany, and were then entered into the database. Amendment was carried by 53 species. Analysis of the amended data indicates the presence of 553 toxic species in Croatian flora, most within the family Ranunculaceae (49), Asteraceae (36) and Fabaceae (36). From the aspect of vulnerability, 4.52 % poisonous plants are located in the Red Book. Only 4 endemic plants are poisonous. Data analysis showed the use of poisonous plants for various purposes: 65.46 % is used as remedies, 27.49 % as food, 24.77 % as a honey plant, 15.01 % as feed additives, 14.1 % in another way (e.g. drugs / smoking, to induce abortion, the religious purposes ...) and 12.84 % as animal food. Using poisonous plants for food or food additive is associated with the uneven distribution of toxins in the plant body, which allows you to use only non-toxic components. Despite the small number of exposure to toxic or harmful plants results in toxicity, there is a need for increased awareness, researching and documenting the flora and its properties, because it increases the possibility of economic exploitation and reduces the risk of poisoning and adverse effects.