Procjena primarnih oštećenja DNA u krvi i organima miša nakon izloženosti ionizirajućem zračenju

Modrić, Željka

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master's thesis

Procjena primarnih oštećenja DNA u krvi i organima miša nakon izloženosti ionizirajućem zračenju

Zagreb: University of Zagreb, Faculty of Science, 2012. urn:nbn:hr:217:301540

Modrić, Željka

University of Zagreb
Faculty of Science
Department of Biology

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APA 6th Edition

Modrić, Ž. (2012). Procjena primarnih oštećenja DNA u krvi i organima miša nakon izloženosti ionizirajućem zračenju (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:301540

MLA 8th Edition

Modrić, Željka. "Procjena primarnih oštećenja DNA u krvi i organima miša nakon izloženosti ionizirajućem zračenju." Master's thesis, University of Zagreb, Faculty of Science, 2012. https://urn.nsk.hr/urn:nbn:hr:217:301540

Chicago 17th Edition

Harvard

Modrić, Ž. (2012). 'Procjena primarnih oštećenja DNA u krvi i organima miša nakon izloženosti ionizirajućem zračenju', Master's thesis, University of Zagreb, Faculty of Science, accessed 24 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:301540

Vancouver

Modrić Ž. Procjena primarnih oštećenja DNA u krvi i organima miša nakon izloženosti ionizirajućem zračenju [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2012 [cited 2024 April 24] Available at: https://urn.nsk.hr/urn:nbn:hr:217:301540

IEEE

Ž. Modrić, "Procjena primarnih oštećenja DNA u krvi i organima miša nakon izloženosti ionizirajućem zračenju", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:217:301540

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:301540

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Metadata

Title	Procjena primarnih oštećenja DNA u krvi i organima miša nakon izloženosti ionizirajućem zračenju
Title (english)	Assessment of primary DNA damage in blood and different organs in swiss albino mices after exposure to ionising radiation
Author	Željka Modrić
Mentor	Mirta Milić (mentor)
Mentor	Vesna Benković (sumentor)
Committee member	Mirta Milić (član povjerenstva)
Committee member	Vesna Benković (član povjerenstva)
Committee member	Mladen Kerovec (član povjerenstva)
Granter	University of Zagreb Faculty of Science (Department of Biology) Zagreb
Defense date and country	2012, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Abstract	Primarna oštećenja DNA u perifernoj krvi i organima Swiss albino miša proučavana su tehnikom alkalnog komet testa. Mjerena su oštećenja i popravak neposredno nakon te 2 i 6 sati nakon izlaganja γ-zračenju (60Co), koristeći klinički relevantne doze od 1 i 2 Gy. Većina DNA lezija popravljena je 2 sata nakon zračenja. Stanice mozga obrađene odmah nakon zračenja pokazale su veću količinu oštećenja u usporedbi sa stanicama jetre i bubrega. Dinamika popravka procijenjena je pomoću celularnog DNA indeksa popravka. Stanice mozga i periferni leukociti su pokazali brži i efikasniji popravak, sugerirajući veću radiorezistentnost za primljene doze. Primijećene su značajne razlike u vremenu potrebnom za popravak i dinamici popravka pri korištenim dozama, posebice kod stanica mozga.
Abstract (english)	Primary DNA damage was studied on peripheral blood and different organs in Swiss albino mice using the alkaline comet assay. The damage and repair were measured immediatelly after, 2 and 6 hours after the exposure to γ- radiation (60Co), using clinically relevant doses of 1 and 2 Gy. The majority of DNA lesions had been repaired in first 2 hours after irradiation. Brain cells processed immediately after the exposure showed more damage compared to liver and kidney cells. Dynamics of repair was estimated using cellular DNA repair index. Brain cells and peripheral leucocytes appeared to repair the damage more effectively than liver and kidney cells, suggesting higher radioresistance to administered doses. There was a significant difference in repair time and dynamics comparing the doses, especially in brain cells.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:301540
Study programme	Title: Biology; specializations in: Ecology Course: Ecology Study programme type: university Study level: graduate Academic / professional title: magistar/magistra biologije (magistar/magistra biologije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2018-04-19 10:14:56

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