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master's thesis
Utjecaj okolišnih čimbenika na mehanizam multiksenobiotičke otpornosti gujavice Eisenia fetida, Savigny
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:333751
Babić, Sanja
University of Zagreb
Faculty of Science
Department of Biology

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Babić, S. (2013). Utjecaj okolišnih čimbenika na mehanizam multiksenobiotičke otpornosti gujavice Eisenia fetida, Savigny (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:333751

Babić, Sanja. "Utjecaj okolišnih čimbenika na mehanizam multiksenobiotičke otpornosti gujavice Eisenia fetida, Savigny." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:333751

Babić, Sanja. "Utjecaj okolišnih čimbenika na mehanizam multiksenobiotičke otpornosti gujavice Eisenia fetida, Savigny." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:333751

Babić, S. (2013). 'Utjecaj okolišnih čimbenika na mehanizam multiksenobiotičke otpornosti gujavice Eisenia fetida, Savigny', Master's thesis, University of Zagreb, Faculty of Science, accessed 23 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:333751

Babić S. Utjecaj okolišnih čimbenika na mehanizam multiksenobiotičke otpornosti gujavice Eisenia fetida, Savigny [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 April 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:333751

S. Babić, "Utjecaj okolišnih čimbenika na mehanizam multiksenobiotičke otpornosti gujavice Eisenia fetida, Savigny", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:333751

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TitleUtjecaj okolišnih čimbenika na mehanizam multiksenobiotičke otpornosti gujavice Eisenia fetida, Savigny
Title (english)Influence of environmental factors on multixenobiotic resistance mechanism in earthworm Eisenia fetida, Savigny
AuthorSanja Babić
MentorRoberta Sauerborn Klobučar (mentor)
MentorMirjana Pavlica (mentor)
Committee memberRoberta Sauerborn Klobučar (predsjednik povjerenstva)
Committee memberMirjana Pavlica (član povjerenstva)
Committee memberJasenka Sremac (član povjerenstva)
Committee memberDanijel Orešić (član povjerenstva)
Committee memberMladen Juračić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013-07-02, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Mehanizam multiksenobiotičke otpornosti (MXR) dio je staničnog detoksifikacijskog mehanizma posredovan aktivnošću ABC transportnih proteina. Glavni predstavnici MXR mehanizma su P-glikoprotein (P-gp; ABCB1), multidrug resistance associated proteins (MRP1-5; ABCC1-5) i breast cancer resistance (BCRP; ABCG2) protein. Navedeni transmembranski prijenosnici prisutni su u svim organizmima i predstavljaju prvu liniju obrane organizma. Uz pomoć ATP-a izbacuju iz stanice endogene spojeve, ksenobiotike, uključujući antropogeno stvorene spojeve, spriječavajući na taj način potencijalno toksičan učinak u stanici (organizmu). Bisfenol A, zbog sve šire upotrebe u industriji polikarbonatne plastike postao je sveprisutno okolišno zagađivalo. U ovom radu po prvi puta je identificirana prisutnost MXR mehanizma i identificiran nukleotidni slijed gena koji kodira za P-glikoprotein u gujavici vrste E. fetida. Uz to, u navedenom modelnom organizmu istraživan je utjecaj bisfenola A i onečišćenih uzoraka snijega na MXR mehanizam.
Abstract (english)
Multixenobiotic resistance mechanism (MXR) is cellular detoxification mechanism mediated by the activity of ATP-binding cassette (ABC) transporters. The main representatives of MXR mechanism are P-glycoprotein (P-gp; ABCB1), multidrug resistance associated proteins (MRP; ABCC1-5) and breast cancer resistance (BCRP; ABCG2) protein. These transmembrane efflux proteins are present in all organisms and represent a first line defence mechanism, by extrusion endogenous chemicals, xenobiotics, including man-made chemicals out of the cell (organism), thus preventing toxic effect. Bisphenol A is one of the highest volume chemicals produced worldwide because of their use in the manufacture of polycarbonate plastic. In this study was for the first time identified presence of MXR efflux activity, determined the partial sequence of P-gp/ABCB1 and defined impact of bisphenol A and polluted snow samples on detoxification mechanisms in earthworm Eisenia fetida.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:333751
Study programmeTitle: Enviromental Sciences
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra struke znanosti o okolišu (magistar/magistra struke znanosti o okolišu)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Science
Created on2017-04-25 10:42:01

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