Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR

Pranjić, Paula

prikaz prve stranice dokumenta Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR

master's thesis

Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR

Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:214126

Pranjić, Paula

University of Zagreb
Faculty of Science
Department of Chemistry

Cite this document

APA 6th Edition

Pranjić, P. (2022). Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:214126

MLA 8th Edition

Pranjić, Paula. "Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:214126

Chicago 17th Edition

Harvard

Pranjić, P. (2022). 'Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR', Master's thesis, University of Zagreb, Faculty of Science, accessed 18 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:214126

Vancouver

Pranjić P. Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2025 January 18] Available at: https://urn.nsk.hr/urn:nbn:hr:217:214126

IEEE

P. Pranjić, "Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:214126

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:214126

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Title	Identifikacija i strukturna karakterizacija 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera pomoću sustava LC-SPE/krio-NMR
Title (english)	Identification and structural characterization of 3-trifluoromethoxyphenyl and 3-(3-phenylpropyl) macrozones and their diastereoisomers by LC-SPE/krio-NMR
Author	Paula Pranjić
Mentor	Predrag Novak (mentor)
Committee member	Predrag Novak (predsjednik povjerenstva)
Committee member	Mirta Rubčić (član povjerenstva)
Committee member	Đani Škalamera (član povjerenstva)
Committee member	Tomislav Jednačak (član povjerenstva)
Granter	University of Zagreb Faculty of Science (Department of Chemistry) Zagreb
Defense date and country	2022-02-25, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Chemistry
Abstract	Pojava sve veće otpornosti bakterija na postojeće antibiotike predstavlja ozbiljan zdravstveni problem pa se stoga u području farmaceutske i medicinske kemije ulažu veliki napori u razvoj novih antibiotika. Makrozoni predstavljaju nove konjugate azitromicina i derivata tiosemikarbazida koji pokazuju izvrsnu antibakterijsku aktivnost in vitro na susceptibilne i rezistentne bakterijske sojeve. Proces razvoja novih antibiotika sastoji se od mnogo koraka, pri čemu je izuzetno važna identifikacija farmaceutskih onečišćenja i novosintetiziranih spojeva – potencijalnih antibiotika. U tu svrhu vrlo često se koriste vezani analitički sustavi pomoću kojih se postiže učinkovitije i brže pročišćavanje te identifikacija spojeva u odnosu na klasične tehnike off-line. U ovom diplomskom radu provedena je izolacija i strukturna karakterizacija novosintetiziranih 3-trifluormetoksifenil- i 3-(3-fenilpropil)-makrozona te njihovih dijastereomera, kao i nekih onečišćenja iz reakcijskih smjesa pomoću sustava LC-SPE/krioNMR. Za strukturnu karakterizaciju izoliranih komponenata korištene su jedno- i dvodimenzijske tehnike NMR te spektrometrija masa. Na temelju analize prikupljenih podataka predložene su strukture izoliranih spojeva.
Abstract (english)	Increasing bacterial resistance to existing antibiotics is a serious health problem, and great efforts are being made to discover and develop new antibiotics to overcome this problem. Macrozones are novel conjugates of azithromycin and thiosemicarbazides that show very good in vitro activity against susceptible and resistant bacterial strains. Development of new antibiotics is a multistep process and one of the most important steps is the identification of pharmaceutical impurities and newly synthesized compounds – potential antibiotics. For this purpose, hyphenated systems are very oftenly used to achieve more efficient and faster purification and identification of compounds compared to off-line techniques. In this study, isolation and structural characterization of newly synthesized 3-trifluoromethoxyphenyl- and 3-(3-phenylpropyl)-macrozones and their diastereoisomers, as well as some impurities from reaction mixtures, have been performed using hyphenated system LC-SPE/cryo-NMR. Oneand two-dimensional NMR techniques and mass spectrometry were used for structural characterization of isolated components. Based on the analysis of collected data, the structures of isolated compounds were proposed.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:214126
Project	Number: IP-2018-01-8098 Title: Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije Title: Macrozones, New Conjugates of Macrolide Antibiotics: Design, Synthesis and Interactions Acronym: Makrozoni/Macrozones Leader: Predrag Novak Jurisdiction: Croatia Funder: HRZZ Funding stream: IP
Study programme	Title: Graduate university studies in chemistry; specializations in: Research programme Course: Research programme Study programme type: university Study level: graduate Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2022-03-04 13:21:19