Mehanizmi enzimske selektivnosti

Keresteš, Gaj

prikaz prve stranice dokumenta Mehanizmi enzimske selektivnosti

Download
PDF 768.21 KB

undergraduate thesis

Mehanizmi enzimske selektivnosti

Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:661190

Keresteš, Gaj

University of Zagreb
Faculty of Science
Department of Biology
University of Zagreb
Faculty of Science
Department of Chemistry

Cite this document

APA 6th Edition

Keresteš, G. (2022). Mehanizmi enzimske selektivnosti (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:661190

MLA 8th Edition

Keresteš, Gaj. "Mehanizmi enzimske selektivnosti." Undergraduate thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:661190

Chicago 17th Edition

Harvard

Keresteš, G. (2022). 'Mehanizmi enzimske selektivnosti', Undergraduate thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, accessed 25 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:661190

Vancouver

Keresteš G. Mehanizmi enzimske selektivnosti [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2025 January 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:661190

IEEE

G. Keresteš, "Mehanizmi enzimske selektivnosti", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb; University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:661190

Cite this item: https://urn.nsk.hr/urn:nbn:hr:217:661190

Please login to the repository to save this object to your list.

Metadata

Title	Mehanizmi enzimske selektivnosti
Title (english)	Mechanisms of enzyme selectivity
Author	Gaj Keresteš
Mentor	Ita Gruić-Sovulj (mentor)
Granter	University of Zagreb Faculty of Science (Department of Biology) Zagreb
Granter	University of Zagreb Faculty of Science (Department of Chemistry) Zagreb
Defense date and country	2022-09-19, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Biology
Abstract	Enzimi su biološke makromolekule koje efikasno i selektivno kataliziraju specifične reakcije. Selektivnost enzima se temelji na uspostavljanju specifičnih pozitivnih interakcija s pripadnim supstratima i negativnih interakcija s nepripadnim supstratima u njihovom osnovnom ili prijelaznom stanju. Porodica kimotripsinskih serinskih proteaza obuhvaća enzime koji imaju vrlo različite razine selektivnosti. Za razliku od njih, aminoacil-tRNA-sintetaze (aaRS) su enzimi koji različitim mehanizmima postižu izrazito visoke razine selektivnosti – u sintetskoj reakciji njihova selektivnost doseže fizikalno-kemijske granice, a kasnije se dodatno povećava mehanizmima popravka pogreške. Tijekom evolucije većina enzima prati trend sužavanja supstratne specifičnosti i povećanja selektivnosti, pri čemu selektivnost može biti selektirana izravno ili se razviti kao posljedica optimizacije katalitičke efikasnosti. Evolucija aaRS prati ovaj trend te je aktivno utjecala na razvoj suvremenog genetičkog koda.
Abstract (english)	Enzymes are biological macromolecules that efficiently and selectively catalyze specific reactions. Enzyme selectivity is based on establishing specific positive interactions with cognate substrates and negative interactions with noncognate substrates in their ground or transition states. The chymotrypsin family of serine proteases includes enzymes with very different levels of selectivity. Conversely, aminoacyl-tRNA synthetases (aaRS) are enzymes which, through various mechanisms, achieve extremely high levels of selectivity – their selectivity in the synthetic reaction reaches physicochemical limits and is later additionally increased by proofreading. Throughout evolution, most enzymes followed the trend of narrowing substrate specificity and increasing selectivity. Selectivity can be directly selected for or developed as a consequence of optimizing catalytic efficiency. The evolution of aaRS follows this trend and actively influenced the development of the contemporary genetic code.
Keywords
Keywords (english)
Language	croatian
URN:NBN	urn:nbn:hr:217:661190
Study programme	Title: Molecular Biology Study programme type: university Study level: undergraduate Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of the Faculty of Science
Created on	2022-10-04 09:26:18