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undergraduate thesis
Antitumorsko djelovanje biljke Camellia sinensis
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:567621
Jurić, Ivana
University of Zagreb
Faculty of Science
Department of Biology

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Jurić, I. (2017). Antitumorsko djelovanje biljke Camellia sinensis (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:567621

Jurić, Ivana. "Antitumorsko djelovanje biljke Camellia sinensis." Undergraduate thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:567621

Jurić, Ivana. "Antitumorsko djelovanje biljke Camellia sinensis." Undergraduate thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:567621

Jurić, I. (2017). 'Antitumorsko djelovanje biljke Camellia sinensis', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 17 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:567621

Jurić I. Antitumorsko djelovanje biljke Camellia sinensis [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 April 17] Available at: https://urn.nsk.hr/urn:nbn:hr:217:567621

I. Jurić, "Antitumorsko djelovanje biljke Camellia sinensis", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:567621

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Metadata
TitleAntitumorsko djelovanje biljke Camellia sinensis
Title (english)Antitumor activity of plant Camellia sinensis
AuthorIvana Jurić
MentorInga Marijanović (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2017-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Camellia sinensis pripada biljnoj porodici Theaceae te postoji u obliku zimzelenog grmlja ili malih stabala čiji se listovi i pupoljci koriste za proizvodnju čaja.Ukoliko ih se promatra s obzirom na "fermentaciju", postoje tri glavne skupine čajeva: nefermentirani (zeleni i bijeli čaj), djelomično fermentirani (oolong čaj) i potpuno fermentirani (crni čaj). S obzirom na to da se Camellia sinensisubraja u ljekovito bilje, ova biljka čajevca, zbog svojih kemijskih spojeva,ima važnu ulogu u prevenciji i liječenju tumora. Polifenolzelenog čaj EGCGuspješno obustavlja proliferaciju linije tumorskih stanica dojkeMCF-7/BOS stimuliranu djelovanjem okolišnog estrogena PCB 102. TakoĎer je ispitivan potencijalni citotoksični i prooksidativni učinak ekstrakta zelenog čaja i dva glavna flavonoida, epigalokatehin galata(EGCG) i epikatehin galata (ECG), na tumorskestanične linije grkljana (HEp2) i njezinu križno-rezistentnu staničnu liniju CK2. EGCG i ekstrakt zelenog čaja povećavaju oštećenje DNA u staničnoj liniji CK2 tijekom kratkog izlaganja. Citotoksičnost EGCG i ECG se povećava s vremenom inkubacije, dok je ekstrakt zelenog čaja izazvao peroksidaciju lipida ustaničnoj liniji CK2. Ispitivan je i ekstrakt bijelog čaja koji inhibira proliferaciju stanica tumora debelog crijeva HT-29, a štiti normalne stanice 3T3-L1 od oštećenja DNA vodikovim peroksidom. U ovom radu se nastoje istaknuti mogući korisni ljekoviti učinci biljke Camellia sinensis u kemoprevenciji i kemoterapiji različitih tipova stanica raka.
Abstract (english)
Camellia sinensis is a species of evergreen shrub or small tree whose leaves and leaf buds are used to produce tea. Concerning to the level of “fermentation”, it can be categorized into three major types: not fermented (green and white tea), partially fermented (oolong tea) and completely fermented (black tea). Camellia sinensis is a medicinal herb that plays an important role in prevention and treatment of tumors. Green tea polyphenol EGCG, suppressed the proliferation-stimulating activity of the environmentalestrogen PCB 102 on MCF-7/BOS breast cancer cells. Potential cytotoxic and prooxidative effects of green tea extract and its two main flavonoid constituents epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) were also observed when tasted on human laryngeal carcinoma cell line (HEp2) and it's crossresistant CK2 cell line. The results showed that EGCG and green tea extract increased the DNA damage in the CK2 cell line during short exposure. The cytotoxicity of EGCG and ECG increased with the time of incubation. Green tea extract induced lipid peroxidation in the CK2 cell line. White tea extract, that inhibits the proliferation of HT-29 colon tumor cells and protects normal 3T3-L1 cells from DNA damage by hydrogen peroxide, was also explored. This paper presents a brief overview of beneficial therapeutic effects of Camellia sinensis in chemoprevention and chemotherapy of different cancer cells types.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:567621
Study programmeTitle: Ecology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of the Faculty of Science
Created on2017-10-20 11:47:42

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