Electronic Properties Of The Protein From The Oxidoreductase Family

Matekalo, Jelena

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master's thesis

Electronic Properties Of The Protein From The Oxidoreductase Family

Split: University of Split, Faculty of Science, 2023. urn:nbn:hr:166:651805

Matekalo, Jelena

University of Split
Faculty of Science
Department of Physics

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APA 6th Edition

Matekalo, J. (2023). Electronic Properties Of The Protein From The Oxidoreductase Family (Master's thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:651805

MLA 8th Edition

Matekalo, Jelena. "Electronic Properties Of The Protein From The Oxidoreductase Family." Master's thesis, University of Split, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:166:651805

Chicago 17th Edition

Matekalo, Jelena. "Electronic Properties Of The Protein From The Oxidoreductase Family." Master's thesis, University of Split, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:166:651805

Harvard

Matekalo, J. (2023). 'Electronic Properties Of The Protein From The Oxidoreductase Family', Master's thesis, University of Split, Faculty of Science, accessed 15 March 2025, https://urn.nsk.hr/urn:nbn:hr:166:651805

Vancouver

Matekalo J. Electronic Properties Of The Protein From The Oxidoreductase Family [Master's thesis]. Split: University of Split, Faculty of Science; 2023 [cited 2025 March 15] Available at: https://urn.nsk.hr/urn:nbn:hr:166:651805

IEEE

J. Matekalo, "Electronic Properties Of The Protein From The Oxidoreductase Family", Master's thesis, University of Split, Faculty of Science, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:166:651805

Cite this item: https://urn.nsk.hr/urn:nbn:hr:166:651805

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Metadata

Title	Electronic Properties Of The Protein From The Oxidoreductase Family
Title (croatian)	Elektronska svojstva proteina iz klase oksidoreduktaza
Author	Jelena Matekalo
Mentor	Željka Sanader Maršić (mentor)
Mentor	Martina Perić Bakulić (pomoć pri izradi, neposredni voditelj)
Committee member	Željka Sanader Maršić (predsjednik povjerenstva)
Committee member	Bernarda Lovrinčević (član povjerenstva)
Committee member	Martina Perić Bakulić (član povjerenstva)
Granter	University of Split Faculty of Science (Department of Physics) Split
Defense date and country	2023-09-22, Croatia
Scientific / art field, discipline and subdiscipline	NATURAL SCIENCES Physics
Abstract	Electron transfer between the redox protein PQQ-GDH and carbon nanotubes, acting as a bioelectrode, has been accomplished in recent decades. In this time, the focus has been on investigating the suitability of carbon nanotubes as bioelectrodes. The reason for this lies in the biomedical applications, specifically the electron transfer between proteins and bioelectrodes, which forms the basis for the development of small medical devices. In cells, proteins are found in the cellular medium and mostly have free movement. However, to become a part of a bioelectrode, they need to be immobilized on the surface. Therefore, it is crucial to thoroughly understand the mechanism of their activity in order to influence this activity and ensure that enzymes remain active even when immobilized. The initiation of this research involves observing the electronic structure of the active site of the PQQ-GDH system before and after the electron transfer reaction occurs. The study was conducted using the Density Functional Theory (DFT) method, a Quantum Mechanical (QM) method, to determine the molecular geometry and electronic structure of the molecular system.
Abstract (croatian)	Prijenos elektrona između redoks proteina PQQ-GDH i ugljikove nanocijevi, koja djeluje kao bioelektroda, značajno je područje istraživanja je u posljednjih nekoliko desetljeća. U ovom razdoblju fokus je na ispitivanju prikladnosti ugljikovih nanocijevi kao bioelektroda. Razlog tome je biomedicinske prirode, odnosno prijenos elektrona između proteina i bioelektroda temelj je razvoja malih medicinskih uređaja. U stanicama proteini se nalaze u staničnom mediju i većinom imaju slobodno gibanje. Međutim, da bi bili dio bioelektroda, moraju biti imobilizirani na površini. Zato je bitno rauzmjeti detaljno mehanizam njihove aktivnosti, kako bi se moglo utjecati na tu aktivnost i osigurati da su enzimi aktivni i kad su imobilizirani. Začetak ovog istraživanja je na promatranju elektronske strukture aktivnog mjesta sustava proteina pirolokinolin kinon ovisna glukoza dehidrogenaza (PQQ-GDH) prije te nakon što se dogodi reakcija prijenosa elektrona. Istraživanje je odrađeno metodom teorije funkcionala gustoće (DFT), jednom od metoda kvantne mehanike, kojom je određena molekularna geometrija te elektronska struktura proučavanog molekularnog sustava.
Keywords
Keywords (croatian)
Language	english
URN:NBN	urn:nbn:hr:166:651805
Study programme	Title: Physics; specializations in: major in teaching, major in Astrophysics, major in Biophysics, major in Enviromental physics, major in Computational physics, major in Astrophysics and physics of elemental particles Course: major in Biophysics Study programme type: university Study level: graduate Academic / professional title: magistar/magistra fizike (magistar/magistra fizike)
Type of resource	Text
File origin	Born digital
Access conditions	Open access
Terms of use
Repository	Repository of Faculty of Science
Created on	2023-09-25 12:50:34