Medication-related osteonecrosis of the jaw represents the dying of the osseous part of the jaw in patients under antiresorptive and antiangiogenic therapy. The emergence of osteonecrosis is a complicated combination of appropriate drugs, general state of the organism, presence of local inflammation and types of dental treatments. The most common drugs which usually lead to the emergence of osteonecrosis are antiresorptive drugs: bisphosphonates and denosumabs. Osteonecrosis affects jaws exclusively, probably because of the highest rate of remodelling in regard to other bones in human body and a thin mucosa which contributes to the easier penetration of microorganisms from oral media into the bone. Considering the clinical picture, osteonecrosis can be divided in four stages. In advanced cases pathological fractures are present and they significantly distort patient's quality of life. The therapy for osteonecrosis is focused on raising the patient's quality of life, which is achieved by alleviating pain, inflammation, unpleasant smell and finally, a prosthetic remedy to the oral cavity. The necrotic part of the bone is usually surgically removed. Defects that occur after the surgical removal are sanitized in different ways. One of the latest methods of sanitizing defects is the use of PRGF-Endoret technology. PRGF is derived from a patient's blood, which makes it a 100% autologous “drug”. It contains numerous growth factors, such as platelet-derived growth factor (PDGF), transformative growth factor β (TGF-β), insulin growth factor (IGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), angiopoietin-1. In that way, PRGF stimulates cell proliferation and collagen synthesis, which in turn leads to faster and more adequate wound healing. Osteonecrosis of the jaw can be prevented with proper education of doctors of dental medicine on drugs as well as with protocols on how to treat patients who are taking the mentioned drugs. Also, patients’ education and motivation are very important.