Tooth loss disrupts the biostatic balance which leads to the deterioration of stomatognathic system functions. Partial loss of teeth can adversely affect the quality of life. Currently, dental implants are widely accepted as a therapeutic solution in the rehabilitation of partial edentulism. For the successful installation of conventional implants, the availability of sufficient bone quantity and quality is essential. Failure to meet this criterion complicates the course of therapy. Bicortical implants are anchored in the basal bone that is present throughout life. The specific design of bicortical implants allows almost all patients to be provided with fixed replacements, regardless of the quantity of sufficient bone. For patients, this means avoiding additional surgical procedures and possible complications, frequent office visits and a long wait for the final restoration. The implantation procedure of the bicortical implants is minimally invasive, less uncomfortable for the patients and contributes to faster recovery. A high rate of success is achieved in the therapy of medically compromised patients where conventional implant therapy would not be possible or successful. Bicortical implants proved to be a possible therapeutic solution of partial edentulism, from the replacement of several teeth to replacements that cover the whole jaw. The concept is not intended for the replacement of an individual tooth. Bicortical or multicortical anchoring is achieved during the procedure and the substitute serves as an immediate splint. This concept of therapy represents a solution in a large number of patients as a reliable and safe treatment of partial edentulism.