In the introductory part of the paper, evidence-based medicine and terminology of different names used for complementary and alternative medicine are defined, the most commonly used forms of alternative and complementary medicine are described, its side effects are explained, and the education of nurses in Croatia and in the world is explained. The aim of this paper was to investigate how well the students of the fifth grade of the secondary school for nurses know about complementary and alterative medicine – CAM and what are the sources of this knowledge. A cross-sectional research was conducted at the School for Nurses Vinogradska in Zagreb. The research was conducted among students of the fifth grade. A group of respondents were students of the fifth grade of medical school, aged 19-20, attending all the school subjects. The students filled an anonymous, structured questionnaire designed for the purpose of this research. A questionnaire of 19 questions contains 18 closed-type questions and 1 open type question. Students were asked to list CAM methods that they or their family members used. They then responded to questions about the sources of information on CAM treatment, CAM forms of treatment, personal attitudes, assessment of their own CAM knowledge, the importance of informing the health care staff that the patient uses the CAM treatment methods, and the attitude about CAM treatment implementation in a school for nurses curriculum. The results show that 72.4% of students believe that CAM should be introduced in nursing education and that 84.7% of students think they do not know enough about CAM treatment methods, and CAM information is not provided by school teachers, but parents or the internet/media. After data processing, it was concluded that students considered it very important for patients to tell their doctors and nurses to use some form of CAM. Those students who already have some knowledge of CAM methods of treatment, regardless of the source of their knowledge, have more often received information about the use of CAM methods. Because of the belief that CAM methods help treat, it is essential to teach students critical thinking and evidence-based medicine.