Title Uloga estrogena i prolaktina u kontroli diferencijacije stanica mliječne žlijezde
Title (english) The Role of Estrogen and Prolactin in Mammary Cells Differentiation Control
Author Marija Žuk
Mentor Nina Poljičak-Milas (mentor)
Committee member Mirna Robić
Committee member Romana Turk
Committee member Nina Poljičak-Milas
Granter University of Zagreb Faculty of Veterinary Medicine (Department of Pathophysiology) Zagreb
Defense date and country 2016-03-29, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Veterinary Medicine Basic and Preclinical Veterinary Sciences
Abstract U svih sisavaca su stanice mliječne žlijezde gotovo jednake strukture bez obzira što se, ovisno o vrsti, kemijski sastav mlijeka jako razlikuje. Diferencijacija mliječne žlijezde započinje u ranom embrionalnom razvoju, no prilikom rođenja mliječna žlijezda je slabo razvijena. Razvoj mliječne žlijezde nastavlja se tijekom spolnog sazrijevanja, a najbrži rast događa se tijekom graviditeta. Svi stadiji diferencijacije i rasta mliječne žlijezde, te njezine kasnije funkcije pod složenom su endokrinološkom kontrolom u koju su uključeni brojni hormoni. Najvažniji među njima su estrogen, progesteron, prolaktin, hormon rasta i inzulinu sličan čimbenik rasta-I, no također i brojni drugi hormoni, između ostalih inzulin, aldosteron te kortizol. Uz to što su uključeni u razvoj tkiva mliječne žlijezde, neki od navedenih hormona su i ključan čimbenik u karcinogenezi toga tkiva. Brojni radovi upućuju na upletenost estrogena i prolaktina i njihovih signalnih putova u proliferaciji stanica sa već postojećom mutacijom ili u povećanju mogućnosti za nastanak mutacija, odnosno u proliferaciji, preživljavanju i pokretljivosti stanica i podržavanju vaskularizacije tumora mliječne žlijezde. Danas je glavni cilj i humane i veterinarske medicine odrediti prognostičke čimbenike pomoću kojih bi se moglo prepoznati terapijske ciljeve za potporno liječenje, bolji ishod i poboljšanje preživljavanja oboljelih. Istraživanja na životinjama in vivo, te organskim kulturama mliječne žlijezde pružila su vrijedna saznanja o brojnim čimbenicima uključenim u diferencijaciju i rast mliječne žlijezde. Godinama se predlagalo da tumor mliječne žlijezde u pasa bude model za proučavanje tumora dojke kod ljudi zbog velikog broja sličnosti, od epidemioloških podataka pa do histoloških uzoraka neoplastičnih lezija. Uz to, velika pojavnost tumora mliječne žlijezde u pasa u relativno kratkom vremenskom razdoblju, jer je njihov životni vijek puno kraći, može se iskoristiti kao prednost u izvođenju kliničkih istraživanja za pronalaženje novih biomarkera potrebnih za rano otkrivanje i potpuniju biokemijsku karakterizaciju tumora dojke u ljudi.
Abstract (english) Mammary gland cells from different species have an almost identical structure irrespective of the fact that the milk secreted by these cells varies widely in its chemical composition from one species to another. Differentiation of mammary gland begins in early embryonic development, but at birth mammary gland is poorly developed. The growth of the mammary gland continues during puberty and the fastest growth occurs during pregnancy. All stages of differentiation and development of the mammary gland and its later function are under complex endocrine control, in which various hormones are included. The most important between them are estrogen, progesterone, prolactine, growth hormone and insuline.like growth factor-I, but also a number of other hormones, including insulin, cortisol and aldosterone. In addition to being involved in the development of mammary gland, some of these hormones are a key factor in the carcinogenesis of that tissue. Many papers indicate on the involvement of estrogen and prolactin and their signal pathways in cell proliferation with already existing mutation or on increase opportunities for the occurrence of mutations, or in proliferation, survival and motility of cells and supporting vascularization of the mammary gland tumors. Nowadays, one of the major goals in human and veterinary medicine is to identify prognostic factors that could identify therapeutic targets to support a better outcome and to improve survival. Research on animals in vivo, and on organic cultures of mammary gland provided valuable information on various factors involved in the growth and differentiation of the mammary gland. Canine mammary tumors have been suggested as a model to study human breast cancer, for a number of years due to the great number of similarities between them, from epidemiological dana to the histological patterns of the neoplastic lesions. In addition, the high incidence of mammary tumors in dogs in relatively short period, because of their shorter lifetime, can be used as an advantage in carrying out clinical trials for earlier detection and more complete biochemical characterization of breast cancer.
Keywords
endokrina regulacija
mliječna žlijezda
stanična diferencijacija
Keywords (english)
endocrine regulation
mammary gland
cell diferentiation
Language croatian
URN:NBN urn:nbn:hr:178:883569
Study programme Title: Veterinary Medicine Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
Type of resource Text
File origin Born digital
Access conditions Access restricted to students and staff of home institution
Terms of use
Repository Repository of Faculty of Veterinary Medicine
Created on 2016-04-11 10:33:58