This work presents an overview of the oral vaccination campaign efficiency on the territory of the Republic of Croatia in the period from 2010 to 2017 and the number range of infected foxes across the entire territory of the country. Over a period of seven years, a total number of more than 30,000 foxes were tested on rabies. In addition, a large number of other wild and domestic animals which could represent a potential source of infection, were also tested to rabies. The results show that oral vaccination was an extremely effective method of suppressing this lethal disease in wild and, consequently, in domestic animals, given the fact that after almost 40 years of permanent existence of rabies on our territory, the disease was finally eradicated. Prior to the commencement of the oral vaccination campaign in 2010, we have 15.8 % positive specimens of all foxes tested on rabies, and after just one oral immunization campaign, a year later, this percentage decreased to 9 % of the positive individuals. For just four years since the beginning of the oral vaccination campaign, none of the animals tested in the Republic of Croatia had been infected with the rabies virus, indicating the high effectiveness of the actions taken. The results of the study indicate the extremely positive effect of the oral vaccination campaign on controlling and suppressing the reservoirs and vectors of rabies, and at the same time indicate the need of continuous oral immunization if we want to keep this dangerous infection under control, and in the foreseeable future to acquire the status of the country free of rabies.