Duchenne's muscular dystrophy is a progressive disease that affects muscle cells and thus muscle tissue becomes fat and connective tissue. The lack of dystrophin protein in the muscles leads to a progressive decline in muscle strength. Precisely because of this, the first clinical symptom is weakness of the proximal muscles, and the most common sign of the disease is Gowers' sign, which indicates a specific way of straightening the body. The disease affects boys, and the physiotherapy approach plays a very important role in slowing down the progression of the disease and maintaining independence and motor functions as long as possible. The disease is incurable and is divided into three stages of the disease: the early stage of independent walking, the transitional stage of difficulties with walking and the stage of loss of mobility. On the basis of the performed physiotherapy assessment, a physiotherapy intervention is carried out, which is focused on the symptoms and the stage of the disease. It is recommended to carry out stretching, strengthening and coordination exercises, as well as breathing exercises and postural training. In addition to the above, in advanced stages of the disease, orthoses and splints and wheelchairs are used. Of particular importance is the prevention of the development of contractures and postural deviations, as well as respiratory physiotherapy. Also, education of the parents and the patient is very important, as is the modification of the space in the house.