Acne is an inflammatory skin disease that mostly affects people in adolescence and puberty, with possibility of continuing the disease into adulthood. Acne is caused by changes in the pilosebaceal unit. Although more researches are needed on the onset of acne, many scientists have linked it to the genetic background, diet, stress, hormonal imbalance and skin type of an individual. The medical treatment for acne depends on the type of acne. This paper provides an overview of all side effects of medicinal product belonging to ATC: D10 group reported to the Croatian Agency for Medicinal Products and Medical Devices (HALMED) from January 1, 2018 to January 31, 2018. In total, 141 suspected adverse drug reactions from ATC:D10 group were analyzed and the results are divided by patient's age and gender, reporter qualification, seriousness criteria, outcome, affiliation of adverse reactions according to the Medical Dictionary of Regulatory Affairs (MedDRA) organic system classification and active substance. The proportion of reports of adverse drug reactions of D10 group in the total number of reports of adverse drug reactions was 3.1%. In total, 369 adverse drug reactions were analyzed and most of them are related to female patients (64.5%) and the 18-44 patient age group (39.7%). Most adverse reactions were reported by pharmacists (43.3%) and were not serious. The most common side effects for drugs from ATK: D10 group were reported for azithromycin (23.1%), methylprednisolone (21.4%), clindamycin (13.3%), dexamethasone (9.8%), and doxycycline (8.7%), and the highest number of side effects resulted in patient-free recovery (35.2%). The data are compared with the European and world-wide database of side effects of medicines, and there is a clear coincidence in most of the data.