Background: Even though there is an evidence of physical activity being good for mental health, there is less evidence of consistency between physical activity and mental activity after experiencing natural disaster, like earthquake. Consequently, after earthquakes, mental problems and disorders often occur in survivors. Aim: The aim of this study was to examine whether there is a link between physical activity (physical activity and inactivity), with mental health of people living in earthquake-affected areas see if the frequency of physical activity of these people has changed since the earthquake. Respondents and methods: In research there has been 45 respondents in which 18 of them were in examined (physically active) group and 27 respondents in control group (inactive). Out of entire group, there was 30 females and 15 male respondents. In examined group there was 11 female, and 7 male respondents, and in control group 19 female and 8 male respondents. Through internet pattern Google forms respondents have taken survey questionnaire which was made out of 13 questions with informative character and survey for examination of psychopathological status with CORE-OM. Results: A statistically significant difference in the frequency of physical activity of the subjects before and after the earthquake was found between the examined and control group of examinees (p = 0.0005). Statistical analysis showed that there is a difference between male and female respondents in how many hours per week they spend some form of physical activity in the Fitness Center / gym (p = 0.019). It has been proven that the subjects of the examined group mostly use a combination of aerobic and anaerobic exercises.It was found that statistically more respondents in the study group feel positive and better than usual after training / exercise. There is no statistically significant difference in mental health was found between physically active and physically inactive people living in the areas affected by the earthquake. Conclusion: Results of this research can be used for further examination on connection between physical activity and mental health of people who live in areas affected by the earthquake.